Qing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling.
Rui WangDan-Feng LiYi-Fang HuQiang LiaoTian-Tian JiangOpeyemi Joshua OlatunjiKui YangJian ZuoPublished in: Drug design, development and therapy (2021)
QLY was potent in promoting PPAR-γ expression and consequently disrupted inflammatory feedback in WAT by altering monocytes/macrophages polarization and adipocytes differentiation.
Keyphrases
- adipose tissue
- oxidative stress
- insulin resistance
- diabetic rats
- poor prognosis
- dendritic cells
- peripheral blood
- high glucose
- rheumatoid arthritis
- early stage
- high fat diet induced
- fatty acid
- drug induced
- long non coding rna
- anti inflammatory
- type diabetes
- binding protein
- resting state
- immune response
- skeletal muscle
- endothelial cells
- functional connectivity