Chitosan reduces inflammation and protects against oxidative stress in a hyperlipidemic rat model: relevance to nonalcoholic fatty liver disease.
Raushan KumarJitendra Kumar AryaSyed Ibrahim RizviPublished in: Molecular biology reports (2022)
The findings suggest that Chitosan can effectively improve liver lipid metabolism by normalizing cholesterol, triglyceride, lowering NF-KB expression, and protecting the liver from oxidative stress by improving hepatic function. Chitosan also regulates genes related to lipidemic stress i,e leptin and adiponectin.
Keyphrases
- oxidative stress
- drug delivery
- wound healing
- dna damage
- diabetic rats
- hyaluronic acid
- ischemia reperfusion injury
- induced apoptosis
- poor prognosis
- signaling pathway
- metabolic syndrome
- low density lipoprotein
- genome wide
- pi k akt
- cell proliferation
- fatty acid
- insulin resistance
- lps induced
- adipose tissue
- gene expression
- dna methylation
- long non coding rna
- liver fibrosis
- transcription factor