Transcriptional changes after herpes simplex virus type 1 infection in human trabecular meshwork cells.

Jin A ChoiHyun-Hee JuJu-Eun KimSeon-Kyu KimDonghyun JeeJiyoung LeeChan Kee ParkSoon-Young Paik

Published in: PloS one (2019)

In human TM cells, HSV-1 induced transcriptional suppression of many components related to fibrosis and enhanced expression of both PDGF-BB and MCP-1. Our study may provide a novel mechanism for the pathogenesis of HSV-1 infection in TM cells.

Keyphrases

induced apoptosis
herpes simplex virus
cell cycle arrest
endothelial cells
endoplasmic reticulum stress
poor prognosis
transcription factor
cell death
high glucose
long non coding rna
body composition
pluripotent stem cells
heat shock
pi k akt
postmenopausal women