Metabolic Profiling of Blood and Urine for Exploring the Functional Role of the Microbiota in Human Health.
Ana F DialloMark B LockwoodKatherine Anne MakiAlexis T FranksAbhrarup RoyRosario B Jaime-LaraPaule Valery JosephWendy A HendersonSeon Yoon ChungJacqueline McGrathStefan J GreenAnne M FinkPublished in: Biological research for nursing (2020)
The quantification of metabolites in blood and urine allows nurses to explore new hypotheses about the microbiome. This review summarizes findings from recent studies with a focus on how the state of the science can influence future nursing research initiatives. Metabolomics can advance nursing research by identifying physiologic/pathophysiologic processes underlying patients' symptoms and can be useful for testing the effects of nursing interventions. To date, metabolomics has been used to study cardiovascular, respiratory, endocrine, autoimmune, and infectious conditions, with research focused on understanding the microbial metabolism of substrates resulting in circulating/excreted biomarkers such as trimethylamine N-oxide. This review provides specific recommendations for the collection of specimens and goals for future studies.
Keyphrases
- mental health
- human health
- healthcare
- quality improvement
- risk assessment
- end stage renal disease
- mass spectrometry
- current status
- ejection fraction
- newly diagnosed
- chronic kidney disease
- case control
- multiple sclerosis
- public health
- physical activity
- ms ms
- peritoneal dialysis
- single cell
- patient reported outcomes
- clinical practice
- sleep quality
- depressive symptoms
- drug induced
- global health