Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.
Aeron M SmallGina M PelosoJason LinefskyJayashri AragamAshley GallowayVidisha TanukondaLu-Chen WangZhi YuMargaret Sunitha SelvarajEric H Farber-EgerMichael T BakerShefali Setia VermaSimon S K LeeMichael H PreussMarylyn DeRiggi RitchieScott M DamrauerDaniel James RaderQuinn S WellsRuth J F LoosSteven A LubitzGeorge ThanassoulisKelly ChoPeter W F Wilsonnull nullPradeep NatarajanChristopher J O'DonnellPublished in: Circulation (2023)
We performed a multiancestry GWAS in CAS and identified 6 novel genomic regions in the disease. Secondary analyses highlighted the roles of lipid metabolism, inflammation, cellular senescence, and adiposity in the pathobiology of CAS and clarified the shared and differential genetic architectures of CAS with atherosclerotic cardiovascular diseases.
Keyphrases
- genome wide association study
- crispr cas
- genome editing
- aortic stenosis
- genome wide
- transcatheter aortic valve replacement
- ejection fraction
- aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve
- cardiovascular disease
- copy number
- oxidative stress
- dna methylation
- insulin resistance
- quality improvement
- dna damage
- coronary artery disease
- gene expression
- stress induced
- heart failure
- type diabetes
- physical activity
- fatty acid
- skeletal muscle
- metabolic syndrome