Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain.
Wesley L CaiCeleste B GreerJocelyn F ChenAnna Arnal-EstapéJian CaoQin YanDon X NguyenPublished in: BMC medical genomics (2020)
We identify distinctive epigenomic properties of breast cancer cells that metastasize to the lung and brain. We also demonstrate that signatures of active chromatin sites are partially linked to human breast cancer subtypes with poor prognosis, and that specific TFs can independently distinguish lung and brain relapse.
Keyphrases
- poor prognosis
- transcription factor
- resting state
- white matter
- long non coding rna
- genome wide
- gene expression
- breast cancer cells
- functional connectivity
- dna damage
- squamous cell carcinoma
- endothelial cells
- cerebral ischemia
- small cell lung cancer
- multiple sclerosis
- brain injury
- young adults
- blood brain barrier
- pluripotent stem cells