Early Modeled Longitudinal CA-125 Kinetics and Survival of Ovarian Cancer Patients: A GINECO AGO MRC CTU Study.

Olivier ColombanMichel TodAlexandra LearyIsabelle Ray-CoquardAlain LortholaryAnne Claire Hardy-BessardJacobus PfistererAndreas du Bois Christian Kurzeder Alexander Burges Julien PéronGilles FreyerBenoit You

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Modeled KELIM provides higher predictive and prognostic information based on CA-125 longitudinal kinetics compared with GCIG response criteria during first-line chemotherapy. Integration of this endpoint in guidelines may be considered. Individual KELIM and survival simulations can be calculated at http://www.biomarker-kinetics.org/. Further assessment of the surrogate value of KELIM treatment-related variations in a GCIG meta-analysis is warranted.See related commentary by Maitland et al., p. 5182.

Keyphrases

systematic review
cross sectional
meta analyses
locally advanced
aqueous solution
protein kinase
randomized controlled trial
health information
radiation therapy
rectal cancer
combination therapy
social media