Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [ 11 C]UCB-J Positron Emission Tomography Study.
Negin HollandP Simon JonesGeorge SavulichMichelle NaessensMaura MalpettiDavid J WhitesideDuncan StreetPeter SwannYoung T HongTim D FryerTimothy RittmanEoin MulroyFranklin I AigbirhioKailash P BhatiaJohn T O'BrienJames Benedict RowePublished in: Movement disorders : official journal of the Movement Disorder Society (2023)
We provide in vivo evidence for rapid progressive synaptic loss, correlating with clinical progression in primary tauopathies. Synaptic loss may be an important therapeutic target and outcome variable for early-phase clinical trials of disease-modifying treatments. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.