Distributions of intravenous injected iodine nanoparticles in orthotopic u87 human glioma xenografts over time and tumor therapy.
Sharif M RidwanFerris El-TayyebJames F HainfeldHenry M SmilowitzPublished in: Nanomedicine (London, England) (2020)
Aim: To analyze the localization, distribution and effect of iodine nanoparticles (INPs) on radiation therapy (RT) in advanced intracerebral gliomas over time after intravenous injection. Materials & methods: Luciferase/td-tomato expressing U87 human glioma cells were implanted into mice which were injected intravenously with INPs. Mice with gliomas were followed for tumor progression and survival. Immune-stained mouse brain sections were examined and quantified by confocal fluorescence microscopy. Results: INPs injected intravenously 3 days prior to RT, compared with 1 day, showed greater association with CD31-staining structures, accumulated inside tumor cells more, covered more of the tumor cell surface and trended toward increased median survival. Conclusion: INP persistence and redistribution in tumors over time may enable greater RT enhancement and clinically relevant hypo-fractionated-RT and may enhance INP efficacy.
Keyphrases
- endothelial cells
- radiation therapy
- cell surface
- high grade
- single molecule
- induced pluripotent stem cells
- high resolution
- high dose
- pluripotent stem cells
- optical coherence tomography
- magnetic resonance imaging
- magnetic resonance
- poor prognosis
- small cell lung cancer
- computed tomography
- adipose tissue
- mesenchymal stem cells
- metabolic syndrome
- dual energy
- high throughput
- flow cytometry
- radiation induced
- walled carbon nanotubes
- quantum dots