Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis.
Javier Rodríguez-UbrevaCarlos de la Calle-FabregatTianlu LiLaura CiudadMaria L BallestarFrancesc Català-MollOctavio Morante-PalaciosAntonio Garcia-GomezRaquel CelisFrances HumbyAlessandra NervianiJavier MartinCostantino PitzalisJuan D CañeteEsteban BallestarPublished in: Annals of the rheumatic diseases (2019)
We demonstrate a direct link between RA disease activity and the monocyte methylome through the action of inflammation-associated cytokines. Finally, we have obtained a DNA methylation-based mathematical formula that predicts inflammation-mediated disease activity for RA and other chronic immune-mediated inflammatory diseases.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- oxidative stress
- rheumatoid arthritis patients
- ankylosing spondylitis
- dna methylation
- juvenile idiopathic arthritis
- dendritic cells
- gene expression
- peripheral blood
- interstitial lung disease
- circulating tumor
- single molecule
- cell free
- preterm birth