A B7-H4 targeting antibody-drug conjugate shows anti-tumor activity in PARPi and platinum resistant cancers with B7-H4 expression.

Sarah B Gitto Margaret E Whicker Gareth Davies Sushil Kumar Krista Kinneer Haineng Xu Arthur Lewis Srinivas Mamidi Sergey Medvedv Hyoung Kim Judith Anderton E Jessica Tang Benjamin Ferman Steven Coats Robert W Wilkinson Eric J Brown Daniel J Powell Fiona Simpkins

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

These data support B7-H4 as an attractive ADC target for treatment of drug-resistant HGSOC and provide evidence for activity of an ADC with a DNA-damaging payload in this population.

Keyphrases

drug resistant
multidrug resistant
acinetobacter baumannii
poor prognosis
diffusion weighted imaging
cancer therapy
electronic health record
magnetic resonance imaging
pseudomonas aeruginosa
binding protein
artificial intelligence