Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients.
Laurence M MossMarijke Hyke AlgeraRobert DobbinsFrank GrayStephanie StraffordAmy HeathMonique van VelzenJules A A C HeubergerMarieke NiestersErik OlofsenCeline M LaffontAlbert DahanGeert Jan GroeneveldPublished in: PloS one (2022)
Results from this proof-of-principle study provide the first clinical evidence that high sustained plasma concentrations of buprenorphine may protect against respiratory depression induced by potent opioids like fentanyl.
Keyphrases
- chronic pain
- depressive symptoms
- end stage renal disease
- pain management
- ejection fraction
- newly diagnosed
- placebo controlled
- randomized controlled trial
- diabetic rats
- patient reported outcomes
- drug induced
- physical activity
- oxidative stress
- anti inflammatory
- endothelial cells
- phase ii study
- phase iii
- patient reported