Immunohistochemical Study on the Expression of G-CSF, G-CSFR, VEGF, VEGFR-1, Foxp3 in First Trimester Trophoblast of Recurrent Pregnancy Loss in Pregnancies Treated with G-CSF and Controls.
Fabio ScarpelliniFrancesca Gioia KlingerGabriele RossiMarco SbraciaPublished in: International journal of molecular sciences (2019)
Our study showed that G-CSF treatment increased the number of decidual Treg cells in RPL patients as well as the expression of G-CSF and VEGF in villus trophoblast. These finding may explain the effectiveness of this treatment in RPL, probably regulating the maternal immune response through Tregs recruitment in the decidua, as well as stimulating trophoblast growth.
Keyphrases
- immune response
- poor prognosis
- vascular endothelial growth factor
- newly diagnosed
- randomized controlled trial
- end stage renal disease
- endothelial cells
- systematic review
- induced apoptosis
- ejection fraction
- pregnancy outcomes
- preterm birth
- regulatory t cells
- peritoneal dialysis
- binding protein
- oxidative stress
- body mass index
- combination therapy
- cell death
- cell proliferation
- patient reported outcomes
- long non coding rna
- dendritic cells
- weight gain
- smoking cessation