Clinical and genomic features of classical and basal transcriptional subtypes in pancreatic cancer.

Harshabad Singh Joanne Xiu Kevin S Kapner Chen Yuan Raja R Narayan Matthew J Oberley Alex P Farrell Rishi Surana Brandon M Huffman Kimberley J Perez James M Cleary Alexander C Jordan Andressa Dias Costa Hannah L Williams Srivatsan Raghavan Benjamin A Weinberg Michael J Pishvaian Rachna T Shroff Sanjay Goel Stephanie K Dougan Jonathan Andrew Nowak David B Spetzler George W Sledge Brian M Wolpin Andrew J Aguirre

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

SB subtype is a strong independent predictor of worse outcomes, irrespective of upfront chemotherapy regimen. Clinical trials should investigate PC transcriptional subtypes as a biomarker.

Keyphrases

clinical trial
transcription factor
gene expression
heat shock
locally advanced
randomized controlled trial
type diabetes
phase ii
metabolic syndrome
study protocol
phase iii