The intensification of the aging population is often accompanied by an increase in agerelated diseases, which impair the quality of life of the elderly. The characteristic feature of aging is progressive physiological decline, which is the largest cause of human pathology and death worldwide. However, natural aging interacts in exceptionally complex ways within and between organs, but its underlying mechanisms are still poorly understood. Long non-coding RNA (lncRNA) is a type of noncoding RNA that exceeds 200 nucleotides in length and does not possess protein-coding ability. It plays a crucial role in the occurrence and development of diseases. ANRIL, also known as CDKN2B-AS1, is an antisense ncRNA located at the INK4 site. It can play a crucial role in agerelated disease progression by regulating single nucleotide polymorphism, histone modifications, or post-transcriptional modifications (such as RNA stability and microRNA), such as cardiovascular disease, diabetes, tumor, arthritis, and osteoporosis. Therefore, a deeper understanding of the molecular mechanisms of lncRNA ANRIL in age-related diseases will help provide new diagnostic and therapeutic targets for clinical practice.
Keyphrases
- long non coding rna
- long noncoding rna
- cardiovascular disease
- poor prognosis
- clinical practice
- type diabetes
- endothelial cells
- rheumatoid arthritis
- dna methylation
- gene expression
- binding protein
- nucleic acid
- deep learning
- middle aged
- coronary artery disease
- glycemic control
- small molecule
- adipose tissue
- body composition
- cardiovascular events
- community dwelling
- induced pluripotent stem cells
- cardiovascular risk factors
- amino acid
- pluripotent stem cells