Genetically-regulated pathway-polygenic risk score (GRPa-PRS): A risk stratification method to identify genetically regulated pathways in polygenic diseases.

Xiaoyang Li Brisa S Fernandes Andi LiuYimei LuJingchun Chen Zhong-Ming Zhao Yulin Dai

Published in: medRxiv : the preprint server for health sciences (2023)

, to systematically explore the differential GRPas among individuals stratified by their estimated PRS. The GReX-level comparison among those groups unveiled new insights into the pathways associated with AD risk and resilience. Our framework can be extended to other polygenic complex diseases.

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