Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients.
Emily J TonogaiShan HuangRachel C BothamMatthew R BerryStephen K JoslynGregory B DanielZixin ChenJianghong RaoXiang ZhangFalguni BasuliJohn H RossmeislGregory J RigginsAmy K LeBlancTimothy M FanPaul J HergenrotherPublished in: Neuro-oncology (2021)
Our results suggest PAC-1 + TMZ as a potentially efficacious combination for the treatment of human meningioma, and also demonstrate the utility of including pet dogs with meningioma as a means to assess anticancer strategies for this common brain tumor.