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Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients.

Emily J TonogaiShan HuangRachel C BothamMatthew R BerryStephen K JoslynGregory B DanielZixin ChenJianghong RaoXiang ZhangFalguni BasuliJohn H RossmeislGregory J RigginsAmy K LeBlancTimothy M FanPaul J Hergenrother
Published in: Neuro-oncology (2021)
Our results suggest PAC-1 + TMZ as a potentially efficacious combination for the treatment of human meningioma, and also demonstrate the utility of including pet dogs with meningioma as a means to assess anticancer strategies for this common brain tumor.
Keyphrases
  • high grade
  • optic nerve
  • endothelial cells
  • low grade
  • computed tomography
  • pet ct
  • induced pluripotent stem cells
  • pluripotent stem cells
  • pet imaging
  • combination therapy
  • inflammatory response
  • toll like receptor