Paul J Hergenrother

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 53

Top Topics

Positive Breast Cancer

Reactive Oxygen Species

Acinetobacter Baumannii

Top Venues

Nature chemistry

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Morgan K Gugger, Paul J Hergenrother
A new type of antibiotic targets a drug-resistant bacterium. Nature 625 (7995) (2024)
Amanda J Smith, Paul J Hergenrother
Raptinal: a powerful tool for rapid induction of apoptotic cell death. Cell death discovery 10 (1) (2024)
Kristen A Muñoz, Rebecca J Ulrich, Archit K Vasan, Matt Sinclair, Po-Chao Wen, Jessica R Holmes, Hyang Yeon Lee, Chien-Che Hung, Christopher J Fields, Emad Tajkhorshid, Gee W Lau, Paul J Hergenrother
A Gram-negative-selective antibiotic that spares the gut microbiome. Nature (2024)
Kristen A Muñoz, Rebecca J Ulrich, Archit K Vasan, Matt Sinclair, Po-Chao Wen, Jessica R Holmes, Hyang Yeon Lee, Chien-Che Hung, Christopher J Fields, Emad Tajkhorshid, Gee W Lau, Paul J Hergenrother
A Gram-negative-selective antibiotic that spares the gut microbiome. Nature 630 (8016) (2024)
Morgan K Gugger, Paul J Hergenrother
A new type of antibiotic targets a drug-resistant bacterium. Nature (2024)
Youming Huang, Xinghan Li, Binh Khanh Mai, Emily J Tonogai, Amanda J Smith, Paul J Hergenrother, Peng Liu, Amir H Hoveyda
A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds. Nature chemistry 16 (6) (2024)
Amanda J Smith, Paul J Hergenrother
Raptinal: a powerful tool for rapid induction of apoptotic cell death. Cell death discovery 10 (1) (2024)
Youming Huang, Xinghan Li, Binh Khanh Mai, Emily J Tonogai, Amanda J Smith, Paul J Hergenrother, Peng Liu, Amir H Hoveyda
A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds. Nature chemistry 16 (6) (2024)
Kristen A Muñoz, Rebecca J Ulrich, Archit K Vasan, Matt Sinclair, Po-Chao Wen, Jessica R Holmes, Hyang Yeon Lee, Chien-Che Hung, Christopher J Fields, Emad Tajkhorshid, Gee W Lau, Paul J Hergenrother
A Gram-negative-selective antibiotic that spares the gut microbiome. Nature 630 (8016) (2024)
Kristen A Muñoz, Rebecca J Ulrich, Archit K Vasan, Matt Sinclair, Po-Chao Wen, Jessica R Holmes, Hyang Yeon Lee, Chien-Che Hung, Christopher J Fields, Emad Tajkhorshid, Gee W Lau, Paul J Hergenrother
A Gram-negative-selective antibiotic that spares the gut microbiome. Nature (2024)
Ming Luo, Na Shen, Li Shang, Zeng Fang, Ying Xin, Yuxi Ma, Min Du, Yuan Yuan, Chenchen Hu, Yun Tang, Jing Huang, Wei Wei, Myung Ryul Lee, Paul J Hergenrother, Max S Wicha
Simultaneous Targeting of NQO1 and SOD1 Eradicates Breast Cancer Stem Cells via Mitochondrial Futile Redox Cycling. Cancer research (2024)
Morgan K Gugger, Paul J Hergenrother
A new type of antibiotic targets a drug-resistant bacterium. Nature 625 (7995) (2024)
Youming Huang, Xinghan Li, Binh Khanh Mai, Emily J Tonogai, Amanda J Smith, Paul J Hergenrother, Peng Liu, Amir H Hoveyda
A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds. Nature chemistry (2024)
Brett N Cain, Paul J Hergenrother
Using permeation guidelines to design new antibiotics-A PASsagE into Pseudomonas aeruginosa. Clinical and translational medicine 14 (3) (2024)
Kristen A Muñoz, Rebecca J Ulrich, Archit K Vasan, Matt Sinclair, Po-Chao Wen, Jessica R Holmes, Hyang Yeon Lee, Chien-Che Hung, Christopher J Fields, Emad Tajkhorshid, Gee W Lau, Paul J Hergenrother
A Gram-negative-selective antibiotic that spares the gut microbiome. Nature 630 (8016) (2024)
Kristen A Muñoz, Rebecca J Ulrich, Archit K Vasan, Matt Sinclair, Po-Chao Wen, Jessica R Holmes, Hyang Yeon Lee, Chien-Che Hung, Christopher J Fields, Emad Tajkhorshid, Gee W Lau, Paul J Hergenrother
A Gram-negative-selective antibiotic that spares the gut microbiome. Nature (2024)
Youming Huang, Xinghan Li, Binh Khanh Mai, Emily J Tonogai, Amanda J Smith, Paul J Hergenrother, Peng Liu, Amir H Hoveyda
A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds. Nature chemistry 16 (6) (2024)
Youming Huang, Xinghan Li, Binh Khanh Mai, Emily J Tonogai, Amanda J Smith, Paul J Hergenrother, Peng Liu, Amir H Hoveyda
A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds. Nature chemistry 16 (6) (2024)
Kristen A Muñoz, Rebecca J Ulrich, Archit K Vasan, Matt Sinclair, Po-Chao Wen, Jessica R Holmes, Hyang Yeon Lee, Chien-Che Hung, Christopher J Fields, Emad Tajkhorshid, Gee W Lau, Paul J Hergenrother
A Gram-negative-selective antibiotic that spares the gut microbiome. Nature 630 (8016) (2024)
Amanda J Smith, Paul J Hergenrother
Raptinal: a powerful tool for rapid induction of apoptotic cell death. Cell death discovery 10 (1) (2024)
Brett N Cain, Paul J Hergenrother
Using permeation guidelines to design new antibiotics-A PASsagE into Pseudomonas aeruginosa. Clinical and translational medicine 14 (3) (2024)
Jiangwei Wang, Xiaolin Su, Lingxiang Jiang, Matthew W Boudreau, Lindsay E Chatkewitz, Jessica A Kilgore, Kashif Rafiq Zahid, Noelle S Williams, Yaomin Chen, Shaohui Liu, Paul J Hergenrother, Xiumei Huang
Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms. Cancers 15 (24) (2023)
Jiangwei Wang, Xiaolin Su, Lingxiang Jiang, Matthew W Boudreau, Lindsay E Chatkewitz, Jessica A Kilgore, Kashif Rafiq Zahid, Noelle S Williams, Yaomin Chen, Shaohui Liu, Paul J Hergenrother, Xiumei Huang
Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms. Cancers 15 (24) (2023)
Jiangwei Wang, Xiaolin Su, Lingxiang Jiang, Matthew W Boudreau, Lindsay E Chatkewitz, Jessica A Kilgore, Kashif Rafiq Zahid, Noelle S Williams, Yaomin Chen, Shaohui Liu, Paul J Hergenrother, Xiumei Huang
Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms. Cancers 15 (24) (2023)
Aslamuzzaman Kazi, Alok Ranjan, Vasantha Kumar M V, Bogos Agianian, Martin Garcia Chavez, Vignesh Vudatha, Rui Wang, Rajanikanth Vangipurapu, Liwei Chen, Perry Kennedy, Karthikeyan Subramanian, Jonathan C K Quirke, Francisca Beato, Patrick W Underwood, Jason B Fleming, Jose G Trevino, Paul J Hergenrother, Evripidis Gavathiotis, Said M Sebti
Discovery of KRB-456, a KRAS G12D switch-I/II allosteric pocket binder that inhibits the growth of pancreatic cancer patient-derived tumors. Cancer research communications (2023)
Emily J Geddes, Morgan K Gugger, Alfredo Garcia, Martin Garcia Chavez, Myung Ryul Lee, Sarah J Perlmutter, Christoph Bieniossek, Laura Guasch, Paul J Hergenrother
Porin-independent accumulation in Pseudomonas enables antibiotic discovery. Nature (2023)
Santanu Ghosh, Rachel Yang, Darjan Duraki, Junyao Zhu, Ji Eun Kim, Musarrat Jabeen, Chengjian Mao, Xinyi Dai, Mara R Livezey, Matthew W Boudreau, Ben Ho Park, Erik Russell Nelson, Paul J Hergenrother, David J Shapiro
Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis. Cancer research (2023)
Matthew W Boudreau, Paul J Hergenrother
Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity. RSC medicinal chemistry 13 (6) (2022)
Riley L Svec, Sydney A McKee, Matthew R Berry, Aya M Kelly, Timothy M Fan, Paul J Hergenrother
Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture. ACS chemical biology 17 (2) (2022)
Erica N Parker, Brett N Cain, Behnoush Hajian, Rebecca Joy Ulrich, Emily J Geddes, Sulyman Barkho, Hyang Yeon Lee, John D Williams, Malik Raynor, Diana Caridha, Angela Zaino, Mrinal Shekhar, Kristen A Muñoz, Kara M Rzasa, Emily R Temple, Diana Hunt, Xiannu Jin, Chau Vuong, Kristina Pannone, Aya M Kelly, Michael P Mulligan, Katie K Lee, Gee W Lau, Deborah T Hung, Paul J Hergenrother
An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections. ACS central science 8 (8) (2022)
Matthew W Boudreau, Michael P Mulligan, David J Shapiro, Timothy M Fan, Paul J Hergenrother
Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. Journal of medicinal chemistry 65 (5) (2022)
Kristen A Muñoz, Paul J Hergenrother
Computational discovery of dynobactin antibiotics. Nature microbiology 7 (10) (2022)
Aya M Kelly, Matthew R Berry, Sarah Z Tasker, Sydney A McKee, Timothy M Fan, Paul J Hergenrother
Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy. Journal of the American Chemical Society 144 (27) (2022)
Diana Rose E Ranoa, Robin L Holland, Fadi Ghassan Alnaji, Kelsie J Green, Leyi Wang, Richard L Fredrickson, Tong Wang, George N Wong, Johnny A Uelmen, Sergei Maslov, Zachary J Weiner, Alexei V Tkachenko, Hantao Zhang, Zhiru Liu, Ahmed Ibrahim, Sanjay J Patel, John M Paul, Nickolas P Vance, Joseph G Gulick, Sandeep Puthanveetil Satheesan, Isaac J Galvan, Andrew Miller, Joseph Grohens, Todd J Nelson, Mary P Stevens, P Mark Hennessy, Robert C Parker, Edward Santos, Charles Brackett, Julie D Steinman, Melvin R Fenner, Kirstin Dohrer, Michael DeLorenzo, Laura Wilhelm-Barr, Brian R Brauer, Catherine Best-Popescu, Gary Durack, Nathan C Wetter, David M Kranz, Jessica Breitbarth, Charlie Simpson, Julie A Pryde, Robin N Kaler, Chris Harris, Allison C Vance, Jodi L Silotto, Mark Johnson, Enrique Andres Valera, Patricia K Anton, Lowa Mwilambwe, Stephen P Bryan, Deborah S Stone, Danita B Young, Wanda E Ward, John Lantz, John A Vozenilek, Rashid Bashir, Jeffrey S Moore, Mayank Garg, Julian C Cooper, Gillian E Cooke, Michelle H Lore, Dustin L Yocum, Neal J Cohen, Jan E Novakofski, Melanie J Loots, Randy L Ballard, Mark Band, Kayla M Banks, Joseph D Barnes, Iuliana Bentea, Jessica Black, Jeremy Busch, Abigail R Conte, Madison Conte, Michael Curry, Jennifer Eardley, April Edwards, Therese Eggett, Judes Fleurimont, Delaney Foster, Bruce W Fouke, Nicholas Gallagher, Nicole Gastala, Scott A Genung, Declan Glueck, Brittani Gray, Andrew Greta, Robert M Healy, Ashley Hetrick, Arianna A Holterman, Nahed Ismail, Ian Jasenof, Patrick Kelly, Aaron Kielbasa, Teresa Kiesel, Lorenzo M Kindle, Rhonda L Lipking, Yukari C Manabe, Jade Mayes, Reubin McGuffin, Kenton G McHenry, Agha Mirza, Jada Moseley, Heba H Mostafa, Melody Mumford, Kathleen Munoz, Arika D Murray, Moira Nolan, Nil A Parikh, Andrew S Pekosz, Janna Pflugmacher, Janise M Phillips, Collin Pitts, Mark C Potter, James Quisenberry, Janelle Rear, Matthew L Robinson, Edith Rosillo, Leslie N Rye, MaryEllen Sherwood, Anna Simon, Jamie M Singson, Carly Skadden, Tina H Skelton, Charlie Smith, Mary Stech, Ryan Thomas, Matthew A Tomaszewski, Erika A Tyburski, Scott Vanwingerden, Evette Vlach, Ronald S Watkins, Karriem Watson, Karen C White, Timothy L Killeen, Robert J Jones, Andreas C Cangellaris, Susan A Martinis, Awais Vaid, Christopher B Brooke, Joseph T Walsh, Ahmed Elbanna, William C Sullivan, Rebecca Lee Smith, Nigel Goldenfeld, Timothy M Fan, Paul J Hergenrother, Martin D Burke
Mitigation of SARS-CoV-2 transmission at a large public university. Nature communications 13 (1) (2022)
Nandan Haloi, Archit Kumar Vasan, Emily J Geddes, Arjun Prasanna, Po-Chao Wen, William W Metcalf, Paul J Hergenrother, Emad Tajkhorshid
Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge. Chemical science 12 (45) (2021)
Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk, Sophie Locke, Julian Marschner, Wenjun Li, Spencer Short, Sebastian Doll, Irina Ingold, Bettina Proneth, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Stephen Motika, Paul J Hergenrother, Stefan R Bornstein, Christian Hugo, Jan Ulrich Becker, Kerstin Amann, Hans-Joachim Anders, Daniel Kreisel, Derek A Pratt, Michael Gütschow, Marcus Conrad, Andreas Linkermann
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Nature communications 12 (1) (2021)
Kristen A Muñoz, Paul J Hergenrother
Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria. Accounts of chemical research 54 (6) (2021)
Matthew W Boudreau, Darjan Duraki, Lawrence Wang, Chengjian Mao, Ji Eun Kim, Madeline A Henn, Bingtao Tang, Sean W Fanning, Jeffrey Kiefer, Theodore M Tarasow, Elizabeth M Bruckheimer, Ramon Moreno, Spyro Mousses, Geoffrey L Greene, Edward J Roy, Ben Ho Park, Timothy M Fan, Erik Russell Nelson, Paul J Hergenrother, David J Shapiro
A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Science translational medicine 13 (603) (2021)
Stephen E Motika, Paul J Hergenrother
Re-engineering natural products to engage new biological targets. Natural product reports 37 (11) (2021)
Emily J Tonogai, Shan Huang, Rachel C Botham, Matthew R Berry, Stephen K Joslyn, Gregory B Daniel, Zixin Chen, Jianghong Rao, Xiang Zhang, Falguni Basuli, John H Rossmeisl, Gregory J Riggins, Amy K LeBlanc, Timothy M Fan, Paul J Hergenrother
Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients. Neuro-oncology 23 (10) (2021)
Emily J Geddes, Zhong Li, Paul J Hergenrother
An LC-MS/MS assay and complementary web-based tool to quantify and predict compound accumulation in E. coli. Nature protocols 16 (10) (2021)
Lucia Furiassi, Emily J Tonogai, Paul J Hergenrother
Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity. Angewandte Chemie (International ed. in English) 60 (29) (2021)
Martin Garcia Chavez, Alfredo Garcia, Hyang Yeon Lee, Gee W Lau, Erica N Parker, Kailey E Komnick, Paul J Hergenrother
Synthesis of Fusidic Acid Derivatives Yields a Potent Antibiotic with an Improved Resistance Profile. ACS infectious diseases 7 (2) (2021)
Stephen E Motika, Rebecca Joy Ulrich, Emily J Geddes, Hyang Yeon Lee, Gee W Lau, Paul J Hergenrother
Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch. Journal of the American Chemical Society 142 (24) (2020)
Sarah J Perlmutter, Emily J Geddes, Bryon S Drown, Stephen E Motika, Myung Ryul Lee, Paul J Hergenrother
Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums. ACS infectious diseases 7 (1) (2020)
Matthew W Boudreau, Jessie Peh, Paul J Hergenrother
Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential. ACS chemical biology 14 (11) (2019)
Erica N Parker, Bryon S Drown, Emily J Geddes, Hyang Yeon Lee, Nahed Ismail, Gee W Lau, Paul J Hergenrother
Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens. Nature microbiology 5 (1) (2019)
Evijola Llabani, Robert W Hicklin, Hyang Yeon Lee, Stephen E Motika, Lisa A Crawford, Eranthie Weerapana, Paul J Hergenrother
Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis. Nature chemistry 11 (6) (2019)
Riley L Svec, Paul J Hergenrother
Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations. Angewandte Chemie (International ed. in English) 59 (5) (2019)
Sarah Z Tasker, Amanda E Cowfer, Paul J Hergenrother
Preparation of Structurally Diverse Compounds from the Natural Product Lycorine. Organic letters 20 (18) (2018)
Riley L Svec, Lucia Furiassi, Christine G Skibinski, Timothy M Fan, Gregory J Riggins, Paul J Hergenrother
Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma. ACS chemical biology 13 (11) (2018)
Carlotta Granchi, Serena Fortunato, Serena Meini, Flavio Rizzolio, Isabella Caligiuri, Tiziano Tuccinardi, Hyang Yeon Lee, Paul J Hergenrother, Filippo Minutolo
Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer. Journal of agricultural and food chemistry 65 (28) (2017)
Hyang Yeon Lee, Elizabeth I Parkinson, Carlotta Granchi, Ilaria Paterni, Dipak Panigrahy, Pankaj Seth, Filippo Minutolo, Paul J Hergenrother
Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death. ACS chemical biology 12 (5) (2017)