Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.

Yulin GuoYaojun PengDan GaoMeiying ZhangWeili YangEnqiang LinghuJames G HermanFrançois FuksGuanglong DongMingzhou Guo

Published in: Clinical epigenetics (2017)

HOXD10 is frequently methylated in human HCC, and the expression of HOXD10 is regulated by promoter region methylation. HOXD10 suppresses HCC cell growth both in vitro and in vivo. HOXD10 suppresses human HCC by inhibiting ERK signaling.

Keyphrases

signaling pathway
endothelial cells
dna methylation
pi k akt
induced pluripotent stem cells
cell proliferation
transcription factor
poor prognosis
pluripotent stem cells
genome wide