Aranazoles: Extensively Chlorinated Nonribosomal Peptide-Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339.
Philipp MoosmannReiko UeokaMuriel GuggerJörn PielPublished in: Organic letters (2018)
An analysis of cyanobacterial genomes revealed an architecturally unique biosynthetic gene cluster with an unusually high number of genes encoding predicted iron(II)/α-ketoglutarate-dependent halogenases. Mass spectrometry-guided identification of the corresponding metabolites yielded the aranazoles, extensively halogenated nonribosomal peptide-polyketide hybrids. Their chlorine-bearing fatty acyl-like moiety is reminiscent of the hyperhalogenated chlorosulfolipids, natural products of unknown enzymatic origin that were previously isolated from eukaryotic algae and mussels.
Keyphrases
- mass spectrometry
- multidrug resistant
- genome wide
- genome wide identification
- bioinformatics analysis
- gas chromatography
- fatty acid
- ms ms
- drinking water
- liquid chromatography
- copy number
- high resolution
- genome wide analysis
- capillary electrophoresis
- high performance liquid chromatography
- gene expression
- nitric oxide
- transcription factor
- iron deficiency
- simultaneous determination