Jörn Piel

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 58

Top Topics

Escherichia Coli

Mass Spectrometry

Top Venues

Angewandte Chemie (International ed. in English)

Science (New York, N.Y.)

ACS chemical biology

Nature chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Mathijs F J Mabesoone, Stefan Leopold-Messer, Hannah A Minas, Clara Chepkirui, Pornsuda Chawengrum, Silke Reiter, Roy A Meoded, Sarah Wolf, Ferdinand Genz, Nancy Magnus, Birgit Piechulla, Allison S Walker, Jörn Piel
Evolution-guided engineering of trans -acyltransferase polyketide synthases. Science (New York, N.Y.) 383 (6689) (2024)
Mathijs F J Mabesoone, Stefan Leopold-Messer, Hannah A Minas, Clara Chepkirui, Pornsuda Chawengrum, Silke Reiter, Roy A Meoded, Sarah Wolf, Ferdinand Genz, Nancy Magnus, Birgit Piechulla, Allison S Walker, Jörn Piel
Evolution-guided engineering of trans -acyltransferase polyketide synthases. Science (New York, N.Y.) 383 (6689) (2024)
Daniel Richter, Alicia Courvoisier-Clément, Anna Lisa Vagstad, Sarolt Magyari, Jörn Piel
A structurally conserved helix enables leader-independent tyramine splicing of proteins. Chemical science (2024)
Mathijs F J Mabesoone, Stefan Leopold-Messer, Hannah A Minas, Clara Chepkirui, Pornsuda Chawengrum, Silke Reiter, Roy A Meoded, Sarah Wolf, Ferdinand Genz, Nancy Magnus, Birgit Piechulla, Allison S Walker, Jörn Piel
Evolution-guided engineering of trans -acyltransferase polyketide synthases. Science (New York, N.Y.) 383 (6689) (2024)
Mathijs F J Mabesoone, Stefan Leopold-Messer, Hannah A Minas, Clara Chepkirui, Pornsuda Chawengrum, Silke Reiter, Roy A Meoded, Sarah Wolf, Ferdinand Genz, Nancy Magnus, Birgit Piechulla, Allison S Walker, Jörn Piel
Evolution-guided engineering of trans -acyltransferase polyketide synthases. Science (New York, N.Y.) 383 (6689) (2024)
Sota Yamabe, Kazutoshi Yoshitake, Akihiro Ninomiya, Jörn Piel, Haruko Takeyama, Shigeki Matsunaga, Kentaro Takada
Metagenomic Insights Reveal Unrecognized Diversity of Entotheonella in Japanese Theonella Sponges. Marine biotechnology (New York, N.Y.) (2024)
Mathijs F J Mabesoone, Stefan Leopold-Messer, Hannah A Minas, Clara Chepkirui, Pornsuda Chawengrum, Silke Reiter, Roy A Meoded, Sarah Wolf, Ferdinand Genz, Nancy Magnus, Birgit Piechulla, Allison S Walker, Jörn Piel
Evolution-guided engineering of trans -acyltransferase polyketide synthases. Science (New York, N.Y.) 383 (6689) (2024)
Silja Mordhorst, Thomas Badmann, Nina M Bösch, Brandon I Morinaka, Hartmut Rauch, Jörn Piel, Michael Groll, Anna Lisa Vagstad
Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase. ACS chemical biology 18 (3) (2023)
Silja Mordhorst, Thomas Badmann, Nina M Bösch, Brandon I Morinaka, Hartmut Rauch, Jörn Piel, Michael Groll, Anna Lisa Vagstad
Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase. ACS chemical biology (2023)
Silja Mordhorst, Thomas Badmann, Nina M Bösch, Brandon I Morinaka, Hartmut Rauch, Jörn Piel, Michael Groll, Anna Lisa Vagstad
Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase. ACS chemical biology 18 (3) (2023)
Eike E Peters, Jackson K B Cahn, Alessandro Lotti, Asimenia Gavriilidou, Ursula A E Steffens, Catarina Loureiro, Michelle A Schorn, Paco Cárdenas, Nilani Vickneswaran, Phillip Crews, Detmer Sipkema, Jörn Piel
Distribution and diversity of 'Tectomicrobia', a deep-branching uncultivated bacterial lineage harboring rich producers of bioactive metabolites. ISME communications 3 (1) (2023)
Daniel Richter, Edgars Lakis, Jörn Piel
Site-specific bioorthogonal protein labelling by tetrazine ligation using endogenous β-amino acid dienophiles. Nature chemistry (2023)
Silja Mordhorst, Thomas Badmann, Nina M Bösch, Brandon I Morinaka, Hartmut Rauch, Jörn Piel, Michael Groll, Anna Lisa Vagstad
Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase. ACS chemical biology 18 (3) (2023)
Silja Mordhorst, Thomas Badmann, Nina M Bösch, Brandon I Morinaka, Hartmut Rauch, Jörn Piel, Michael Groll, Anna Lisa Vagstad
Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase. ACS chemical biology 18 (3) (2023)
Franziska Hemmerling, Roy A Meoded, Amy E Fraley, Hannah A Minas, Cora L Dieterich, Michael Rust, Reiko Ueoka, Katja Jensen, Eric J N Helfrich, Cedric Bergande, Maurice Biedermann, Nancy Magnus, Birgit Piechulla, Jörn Piel
Modular Halogenation, α-Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase. Angewandte Chemie (International ed. in English) 61 (11) (2022)
Amy E Fraley, Cora L Dieterich, Mathijs F J Mabesoone, Hannah A Minas, Roy A Meoded, Franziska Hemmerling, Jörn Piel
Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis. Angewandte Chemie (International ed. in English) 61 (39) (2022)
Franziska Hemmerling, Jörn Piel
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery. Nature reviews. Drug discovery 21 (5) (2022)
Masato Kogawa, Rimi Miyaoka, Franziska Hemmerling, Masahiro Ando, Kei Yura, Keigo Ide, Yohei Nishikawa, Masahito Hosokawa, Yuji Ise, Jackson K B Cahn, Kentaro Takada, Shigeki Matsunaga, Tetsushi Mori, Jörn Piel, Haruko Takeyama
Single-cell metabolite detection and genomics reveals uncultivated talented producer. PNAS nexus 1 (1) (2022)
Florian Hubrich, Nina M Bösch, Clara Chepkirui, Brandon I Morinaka, Michael Rust, Muriel Gugger, Serina L Robinson, Anna Lisa Vagstad, Jörn Piel
Ribosomally derived lipopeptides containing distinct fatty acyl moieties. Proceedings of the National Academy of Sciences of the United States of America 119 (3) (2022)
Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M Carroll, Pablo Sánchez, Ahmed A Zayed, Dylan R Cronin, Silvia G Acinas, Peer Bork, Chris Bowler, Tom O Delmont, Josep M Gasol, Alvar D Gossert, André Kahles, Matthew B Sullivan, Patrick Wincker, Georg Zeller, Serina L Robinson, Jörn Piel, Shinichi Sunagawa
Biosynthetic potential of the global ocean microbiome. Nature 607 (7917) (2022)
Silja Mordhorst, Fleur Ruijne, Anna Lisa Vagstad, Oscar Paul Kuipers, Jörn Piel
Emulating nonribosomal peptides with ribosomal biosynthetic strategies. RSC chemical biology 4 (1) (2022)
Reiko Ueoka, Philipp Sondermann, Stefan Leopold-Messer, Yizhou Liu, Rei Suo, Agneya Bhushan, Lida Vadakumchery, Ute Greczmiel, Yoko Yashiroda, Hiromi Kimura, Shinichi Nishimura, Yojiro Hoshikawa, Minoru Yoshida, Annette Oxenius, Shigeki Matsunaga, R Thomas Williamson, Erick M Carreira, Jörn Piel
Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium. Nature chemistry 14 (10) (2022)
Silja Mordhorst, Fleur Ruijne, Anna Lisa Vagstad, Oscar Paul Kuipers, Jörn Piel
Emulating nonribosomal peptides with ribosomal biosynthetic strategies. RSC chemical biology 4 (1) (2022)
Edgars Lakis, Sarolt Magyari, Jörn Piel
In Vivo Production of Diverse β-Amino Acid-Containing Proteins. Angewandte Chemie (International ed. in English) 61 (29) (2022)
Dillon P Cogan, Agneya Bhushan, Reyvin M Reyes, Lingyang Zhu, Jörn Piel, Satish K Nair
Structure and mechanism for iterative amide N -methylation in the biosynthesis of channel-forming peptide cytotoxins. Proceedings of the National Academy of Sciences of the United States of America 119 (13) (2022)
Masato Kogawa, Rimi Miyaoka, Franziska Hemmerling, Masahiro Ando, Kei Yura, Keigo Ide, Yohei Nishikawa, Masahito Hosokawa, Yuji Ise, Jackson K B Cahn, Kentaro Takada, Shigeki Matsunaga, Tetsushi Mori, Jörn Piel, Haruko Takeyama
Single-cell metabolite detection and genomics reveals uncultivated talented producer. PNAS nexus 1 (1) (2022)
Cora L Dieterich, Silke I Probst, Reiko Ueoka, Ioana Sandu, Daniel Schäfle, Michael Dal Molin, Hannah A Minas, Rodrigo Costa, Annette Oxenius, Peter Sander, Jörn Piel
Aquimarins, Peptide Antibiotics with Amino-Modified C-Termini from a Sponge-Derived Aquimarina sp. Bacterium. Angewandte Chemie (International ed. in English) 61 (8) (2021)
Michelle A Schorn, Stefan Verhoeven, Lars Ridder, Florian Huber, Deepa D Acharya, Alexander A Aksenov, Gajender Aleti, Jamshid Amiri Moghaddam, Allegra T Aron, Saefuddin Aziz, Anelize Bauermeister, Katherine D Bauman, Martin Baunach, Christine Beemelmanns, J Michael Beman, María Victoria Berlanga-Clavero, Alex A Blacutt, Helge B Bode, Anne Boullie, Asker Brejnrod, Tim S Bugni, Alexandra Calteau, Liu Cao, Víctor J Carrión, Raquel Castelo-Branco, Shaurya Chanana, Alexander B Chase, Marc G Chevrette, Leticia V Costa-Lotufo, Jason M Crawford, Cameron R Currie, Bart Cuypers, Tam Dang, Tristan de Rond, Alyssa M Demko, Elke Dittmann, Chao Du, Christopher Drozd, Jean-Claude Dujardin, Rachel J Dutton, Anna Edlund, David Peter Fewer, Neha Garg, Julia M Gauglitz, Emily C Gentry, Lena Gerwick, Evgenia Glukhov, Harald Gross, Muriel Gugger, Dulce G Guillén Matus, Eric J N Helfrich, Benjamin-Florian Hempel, Jae-Seoun Hur, Marianna Iorio, Paul R Jensen, Kyo-Bin Kang, Leonard Kaysser, Michael P Snyder, Chung Sub Kim, Ki Hyun Kim, Irina Koester, Gabriele M König, Tiago Leao, Seoung Rak Lee, Yi-Yuan Lee, Xuanji Li, Jessica C Little, Katherine N Maloney, Daniel Männle, Christian Martin H, Andrew C McAvoy, William W Metcalf, Hosein Mohimani, Carlos Molina-Santiago, Bradley S Moore, Michael W Mullowney, Mitchell N Muskat, Louis-Felix Nothias, Ellis C O'Neill, Elizabeth I Parkinson, Daniel Petras, Jörn Piel, Emily C Pierce, Karine Pires, Raphael Reher, Diego Romero, M Caroline Roper, Michael Rust, Hamada Saad, Carmen Saenz, Laura M Sanchez, Søren Johannes Sørensen, Margherita Sosio, Roderich D Süssmuth, Douglas Sweeney, Kapil Tahlan, Regan J Thomson, Nicholas J Tobias, Amaro E Trindade-Silva, Gilles P van Wezel, Mingxun Wang, Kelly C Weldon, Fan Zhang, Nadine Ziemert, Katherine R Duncan, Max Cruesemann, Simon Rogers, Pieter C Dorrestein, Marnix H Medema, Justin Johan Jozias van der Hooft
A community resource for paired genomic and metabolomic data mining. Nature chemical biology 17 (4) (2021)
B Andes Hess, Jörn Piel, Lidia Smentek
Computational studies on the sterol-like cyclization of a monodomain class II terpene cyclase. Organic & biomolecular chemistry (2021)
Madlen Korneli, Sebastian W Fuchs, Katja Felder, Chantal Ernst, Léa V Zinsli, Jörn Piel
Promiscuous Installation of d-Amino Acids in Gene-Encoded Peptides. ACS synthetic biology 10 (2) (2021)
Serina L Robinson, Jörn Piel, Shinichi Sunagawa
A roadmap for metagenomic enzyme discovery. Natural product reports 38 (11) (2021)
Ikenna E Ndukwe, Xiao Wang, Nelson Y S Lam, Kristaps Ermanis, Kelsey L Alexander, Matthew J Bertin, Gary E Martin, Garrett Muir, Ian Paterson, Robert A Britton, Jonathan M Goodman, Eric J N Helfrich, Jörn Piel, William H Gerwick, Robert Thomas Williamson
Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A. Chemical communications (Cambridge, England) 56 (55) (2021)
Alexander O Brachmann, Silke I Probst, Joel Rüthi, Darya Dudko, Helge B Bode, Jörn Piel
A Desaturase-Like Enzyme Catalyzes Oxazole Formation in Pseudomonas Indolyloxazole Alkaloids. Angewandte Chemie (International ed. in English) 60 (16) (2021)
Jackson K B Cahn, Jörn Piel
Opening up the Single-Cell Toolbox for Microbial Natural Products Research. Angewandte Chemie (International ed. in English) 60 (34) (2021)
Britta Frensch, Thorsten Lechtenberg, Michel Kather, Zeynep Yunt, Martin Betschart, Bernd Kammerer, Steffen Lüdeke, Michael Müller, Jörn Piel, Robin Teufel
Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides. Nature communications 12 (1) (2021)
Reiko Ueoka, Roy A Meoded, Alejandro Gran-Scheuch, Agneya Bhushan, Marco W Fraaije, Jörn Piel
Genome Mining of Oxidation Modules in trans-Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides. Angewandte Chemie (International ed. in English) 59 (20) (2020)
Silja Mordhorst, Brandon I Morinaka, Anna Lisa Vagstad, Jörn Piel
Posttranslationally Acting Arginases Provide a Ribosomal Route to Non-proteinogenic Ornithine Residues in Diverse Peptide Sequences. Angewandte Chemie (International ed. in English) 59 (48) (2020)
Fabian M Arnold, Miriam Sarah Weber, Imre Gonda, Marc J Gallenito, Sophia Adenau, Pascal Egloff, Iwan Zimmermann, Cedric A J Hutter, Lea M Hürlimann, Eike E Peters, Jörn Piel, Gabriele Meloni, Ohad Medalia, Markus A Seeger
The ABC exporter IrtAB imports and reduces mycobacterial siderophores. Nature 580 (7803) (2020)
Philipp Moosmann, Felix Ecker, Stefan Leopold-Messer, Jackson K B Cahn, Cora L Dieterich, Michael Groll, Jörn Piel
A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds. Nature chemistry 12 (10) (2020)
Nina M Bösch, Mariana Borsa, Ute Greczmiel, Brandon I Morinaka, Muriel Gugger, Annette Oxenius, Anna Lisa Vagstad, Jörn Piel
Landornamides: Antiviral Ornithine-Containing Ribosomal Peptides Discovered through Genome Mining. Angewandte Chemie (International ed. in English) 59 (29) (2020)
Silke Reiter, Jackson K B Cahn, Vincent Wiebach, Reiko Ueoka, Jörn Piel
Characterization of an Orphan Type III Polyketide Synthase Conserved in Uncultivated "Entotheonella" Sponge Symbionts. Chembiochem : a European journal of chemical biology 21 (4) (2019)
Anna Lisa Vagstad, Takefumi Kuranaga, Salome Püntener, Vijaya R Pattabiraman, Jeffrey W Bode, Jörn Piel
Introduction of d-Amino Acids in Minimalistic Peptide Substrates by an S-Adenosyl-l-Methionine Radical Epimerase. Angewandte Chemie (International ed. in English) 58 (8) (2019)
Guy Schleyer, Nir Shahaf, Carmit Ziv, Yonghui Dong, Roy A Meoded, Eric J N Helfrich, Daniella Schatz, Shilo Rosenwasser, Ilana Rogachev, Asaph Aharoni, Jörn Piel, Assaf Vardi
In plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids. Nature microbiology 4 (3) (2019)
Aysegul Dilsizoglu Senol, Anna Pepe, Clara Grudina, Nathalie Sassoon, Ueoka Reiko, Luc Bousset, Ronald Melki, Jörn Piel, Muriel Gugger, Chiara Zurzolo
Effect of tolytoxin on tunneling nanotube formation and function. Scientific reports 9 (1) (2019)
Maximilian J Helf, Michael F Freeman, Jörn Piel
Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis. Journal of industrial microbiology & biotechnology 46 (3-4) (2019)
Sandra Y Wotzka, Markus Kreuzer, Lisa Maier, Markus Arnoldini, Bidong D Nguyen, Alexander O Brachmann, Dorothée Lisa Berthold, Mirjam Zünd, Annika Hausmann, Erik Bakkeren, Daniel Hoces, Ersin Gül, Markus Beutler, Tamas Dolowschiak, Michael Zimmermann, Tobias Fuhrer, Kathrin Moor, Uwe Sauer, Athanasios Typas, Jörn Piel, Médéric Diard, Andrew J Macpherson, Bärbel Stecher, Shinichi Sunagawa, Emma Slack, Wolf-Dietrich Hardt
Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice. Nature microbiology 4 (12) (2019)
Agneya Bhushan, Peter J Egli, Eike E Peters, Michael F Freeman, Jörn Piel
Genome mining- and synthetic biology-enabled production of hypermodified peptides. Nature chemistry 11 (10) (2019)
Eric J N Helfrich, Reiko Ueoka, Alon Dolev, Michael Rust, Roy A Meoded, Agneya Bhushan, Gianmaria Califano, Rodrigo Costa, Muriel Gugger, Christoph Steinbeck, Pablo Moreno, Jörn Piel
Automated structure prediction of trans-acyltransferase polyketide synthase products. Nature chemical biology 15 (8) (2019)
Eric J N Helfrich, Christine M Vogel, Reiko Ueoka, Martin Schäfer, Florian Ryffel, Daniel B Müller, Silke Probst, Markus Kreuzer, Jörn Piel, Julia A Vorholt
Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome. Nature microbiology 3 (8) (2018)
Reiko Ueoka, Agneya Bhushan, Silke I Probst, Walter M Bray, R Scott Lokey, Roger G Linington, Jörn Piel
Genome-Based Identification of a Plant-Associated Marine Bacterium as a Rich Natural Product Source. Angewandte Chemie (International ed. in English) 57 (44) (2018)
Brandon I Morinaka, Edgars Lakis, Marjan Verest, Maximilian J Helf, Thibault Scalvenzi, Anna Lisa Vagstad, James W Sims, Shinichi Sunagawa, Muriel Gugger, Jörn Piel
Natural noncanonical protein splicing yields products with diverse β-amino acid residues. Science (New York, N.Y.) 359 (6377) (2018)
Roy A Meoded, Reiko Ueoka, Eric J N Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, Jörn Piel
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones. Angewandte Chemie (International ed. in English) 57 (36) (2018)
Philipp Moosmann, Reiko Ueoka, Muriel Gugger, Jörn Piel
Aranazoles: Extensively Chlorinated Nonribosomal Peptide-Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339. Organic letters 20 (17) (2018)
Philipp Moosmann, Reiko Ueoka, Laura Grauso, Alfonso Mangoni, Brandon I Morinaka, Muriel Gugger, Jörn Piel
Cyanobacterial ent-Sterol-Like Natural Products from a Deviated Ubiquinone Pathway. Angewandte Chemie (International ed. in English) 56 (18) (2017)
Maximilian J Helf, Aurelia Jud, Jörn Piel
Enzyme from an Uncultivated Sponge Bacterium Catalyzes S-Methylation in a Ribosomal Peptide. Chembiochem : a European journal of chemical biology 18 (5) (2017)
Reiko Ueoka, Miriam Bortfeld-Miller, Brandon I Morinaka, Julia A Vorholt, Jörn Piel
Toblerols: Cyclopropanol-Containing Polyketide Modulators of Antibiosis in Methylobacteria. Angewandte Chemie (International ed. in English) 57 (4) (2017)
Sebastian W Fuchs, Gerald Lackner, Brandon I Morinaka, Yohei Morishita, Teigo Asai, Sereina Riniker, Jörn Piel
A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution. Angewandte Chemie (International ed. in English) 55 (40) (2016)
Brandon I Morinaka, Marjan Verest, Michael F Freeman, Muriel Gugger, Jörn Piel
An Orthogonal D2 O-Based Induction System that Provides Insights into d-Amino Acid Pattern Formation by Radical S-Adenosylmethionine Peptide Epimerases. Angewandte Chemie (International ed. in English) 56 (3) (2016)