Identification of EPSTI1 as a new potential biomarker for SLE based on GEO database.
Yiying YangHuali ZhangXiaoyu XiaoMuyao GuoPublished in: Clinical rheumatology (2024)
Together, EPSTI1 was found to be a potential biomarker for SLE, closely related to T cell immune imbalance. Key Points • EPSTI1 expression was significantly increased in PBMCs of SLE patients. • EPSTI1 was positively correlated with disease activity and T cell activation- or differentiation-associated genes in SLE patients. • EPSTI1 might have a good diagnostic value for SLE.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- end stage renal disease
- rheumatoid arthritis patients
- ejection fraction
- chronic kidney disease
- ankylosing spondylitis
- newly diagnosed
- prognostic factors
- poor prognosis
- juvenile idiopathic arthritis
- gene expression
- emergency department
- dna methylation
- patient reported outcomes
- genome wide
- bioinformatics analysis
- binding protein
- patient reported