Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors.

Paul J M WijnkerRafeeh DinaniNico C van der LaanSila AlgülBjorn C KnollmannArjan C HouwelingCarol Ann RemmeCoert J ZuurbierDiederik W D KusterJolanda van der Velden

Published in: Cardiovascular research (2024)

SGLT2i (canagliflozin > dapagliflozin > empagliflozin) acutely enhance relaxation in human EHT, especially in HCM and upon prolonged culture. SGLT2i may represent a potential therapy to correct early cardiac dysfunction in HCM.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
endothelial cells
induced pluripotent stem cells
heart failure
oxidative stress
pluripotent stem cells
stem cells
atrial fibrillation
human health