Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosus.

Anna Guiomar Ferreté-BonastreMónica Martínez-GalloOctavio Morante-PalaciosCelia Lourdes CalvilloJosep Calafell-SeguraJavier Rodríguez-UbrevaManel EstellerJosefina Cortés-HernándezEsteban Ballestar

Published in: Annals of the rheumatic diseases (2024)

Disease activity in SLE drives a subversion of the epigenome and transcriptome programme in monocyte differentiation, impacting the function of different subsets and allowing to generate predictive methods for activity and progression.

Keyphrases

disease activity
systemic lupus erythematosus
dna methylation
peripheral blood
rheumatoid arthritis
dendritic cells
rheumatoid arthritis patients
single cell
rna seq
ankylosing spondylitis
gene expression
genome wide
endothelial cells
juvenile idiopathic arthritis
immune response
randomized controlled trial