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Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating.

Mohamad HamiehJorge Mansilla-SotoIsabelle RivièreMichel Sadelain
Published in: Cancer discovery (2023)
Improving the clinical efficacy of CAR T cell therapies will require engineering T cells that overcome heterogeneous and low-abundance target expression while minimizing reactivity to normal tissues. Recent advances in CAR design and logic gating are poised to extend the success of CAR T cell therapies beyond B-cell malignancies.
Keyphrases
  • poor prognosis
  • single cell
  • gene expression
  • binding protein
  • long non coding rna