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Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: A cohort study.

Joshua A BellKaitlin H WadeLinda Marie O'KeeffeDavid CarslakeEmma E VincentMichael V HolmesNicholas John TimpsonGeorge Davey Smith
Published in: PLoS medicine (2021)
In this study, we found that muscle strengthening, as indicated by grip strength gain, was weakly associated with lower atherogenic trait levels in young adulthood, at a smaller magnitude than unfavourable associations of fat mass gain. Associations of muscle mass gain with such traits appear to be smaller and limited to gains occurring in adolescence. These results suggest that body muscle is less robustly associated with markers of CVD susceptibility than body fat and may therefore be a lower-priority intervention target.
Keyphrases
  • cardiovascular disease
  • skeletal muscle
  • depressive symptoms
  • randomized controlled trial
  • genome wide
  • middle aged
  • adipose tissue
  • early life
  • gene expression
  • coronary artery disease
  • cardiovascular events
  • fatty acid