Osteoarthritic infrapatellar fat pad aggravates cartilage degradation via activation of p38MAPK and ERK1/2 pathways.
Zuoqing ZhouSu'an TangXiaoyu NieYiqun ZhangDelong LiYang ZhaoYumei CaoJianwen YinTianyu ChenGuangfeng RuanZhaohua ZhuXiaochun BaiWeiyu HanChanghai DingPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)
Osteoarthritic IPFP induces the degradation and inflammation of cartilage via activation of p38MAPK and ERK1/2 pathways, in which IL-1β and TNF-α act as the key factors. Our study suggests that modulating the effects of IPFP on cartilage may be a promising strategy for knee OA intervention.