Pepsin exposure in a non-acidic environment upregulates mucin 5AC (MUC5AC) expression via matrix metalloproteinase 9 (MMP9)/nuclear factor κB (NF-κB) in human airway epithelial cells.
Yoon Seok ChoiHyung Gyun NaChang Hoon BaeSi-Youn SongYong Dae KimPublished in: International forum of allergy & rhinology (2020)
These findings suggest that pepsin increased MUC5AC expression in non-acidic conditions via the activation of MMP9 and NF-κB in human airway epithelial cells.