IWP-2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro.

Ajjima ChansaenrojChatvadee KornsuthisoponRavipha SuwittayarakSunisa RochanavibhataLai-Keng LoiYu-Cheng LinThanaphum Osathanon

Published in: International endodontic journal (2023)

IWP-2 suppressed inflammatory cytokine expression in both normal and inflamed hDPSCs. Moreover, hDPSCs exerted the immunosuppressive property after IWP-2 treatment. These results suggest the role of Wnt in inflammatory responses and immunomodulation in dental pulp tissues.

Keyphrases

stem cells
endothelial cells
poor prognosis
gene expression
cell proliferation
oxidative stress
induced pluripotent stem cells
pluripotent stem cells
long non coding rna
bone marrow