Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 transfection of guide RNA targeting on MMP9 as anti-cancer therapy in human cutaneous squamous cell carcinoma cell line A431.
Seoh Wei TehAbozer ElderderySanjiv RampalSuresh Kumar SubbiahPooi Ling MokPublished in: Contemporary oncology (Poznan, Poland) (2024)
Our findings provided direct evidence that MMP9 is important in the viability, proliferation, and metastasis of cutaneous SCC cells. It serves as a positive foundation for future CRISPR-based targeted anti-cancer therapies in treating skin cancer and other forms of malignancies that involve MMPs as the key determinants.
Keyphrases
- cancer therapy
- crispr cas
- genome editing
- skin cancer
- squamous cell carcinoma
- drug delivery
- induced apoptosis
- endothelial cells
- signaling pathway
- cell migration
- cell cycle arrest
- genome wide
- current status
- induced pluripotent stem cells
- pluripotent stem cells
- endoplasmic reticulum stress
- oxidative stress
- gene expression
- cell death
- radiation therapy
- locally advanced
- cell proliferation
- pi k akt