Differential in vitro susceptibility to ampicillin/ceftriaxone combination therapy among Enterococcus faecalis infective endocarditis clinical isolates.

Kevin J WestbrookGayatri Shankar ChilambiMadison E StellfoxHayley R NordstromYanhong LiAlina IovlevaNiyati H ShahChelsea E JonesEllen G KlineKevin M SquiresWilliam R MillerTruc T TranCesar A AriasYohei Doi Ryan K Shields Daria Van Tyne

Published in: The Journal of antimicrobial chemotherapy (2024)

We find evidence for diminished in vitro AC activity among a subset of E. faecalis IE isolates with increased pbp4 expression. These findings suggest that alternate antibiotic combinations against diverse contemporary E. faecalis IE isolates should be evaluated.

Keyphrases

combination therapy
genetic diversity
poor prognosis
binding protein
long non coding rna