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Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells.

Svetlana B PaninaJoshua V SchweerQian ZhangGaurav RainaHaley A HardtkeSeungjin KimWanjie YangDionicio SiegelYan Jessie Zhang
Published in: BMC biology (2024)
Our results highlight the efficacy and selectivity of targeting REST alone or in combination as a therapeutic strategy to combat high-REST GBM.
Keyphrases
  • small molecule
  • induced apoptosis
  • endothelial cells
  • cancer therapy
  • cell cycle arrest
  • oxidative stress
  • pluripotent stem cells
  • endoplasmic reticulum stress
  • cell death
  • cell proliferation
  • pi k akt