Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in lethal prostate cancer.

Pradeep Singh Chauhan Irfan Alahi Savar Sinha Elisa M Ledet Ryan Mueller Jessica Linford Alexander L Shiang Jace Webster Lilli Greiner Breanna Yang Gabris Ni Ha X Dang Debanjan Saha Ramandeep K Babbra Wenjia Feng Peter K Harris Faridi Qaium Dzifa Yawa Duose Alexander Sanchez-Espitia Alexander D Sherry Ellen B Jaeger Patrick J Miller Sydney A Caputo Jacob J Orme Fabrice Lucien Sean S Park Chad Tang Russell K Pachynski A Oliver Sartor Christopher A Maher Aadel A Chaudhuri

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We analyzed a total of 220 mCRPC patients, validated the importance of cell-free AR/enhancer alterations as a prognostic biomarker in lethal mCRPC and showed that the underlying mechanism for lethality involves reprogramming developmental states toward increased stemness.

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