Cytochrome P450 2E1-dependent hepatic ethanol metabolism induces fatty acid-binding protein 4 and steatosis.
Neha AttalEmilio MarreroKyle J ThompsonIain H McKillopPublished in: Alcoholism, clinical and experimental research (2022)
CYP2E1-dependent ethanol metabolism inhibits SIRT1-FOXO1 signaling, which leads to increased FABP4 mRNA expression, FABP4 protein secretion, and neutral lipid accumulation. These data suggest that FABP4 released from steatotic hepatocytes could play a role in promoting tumor cell expansion in the setting of ALD and represents a potential target for therapeutic intervention.
Keyphrases
- binding protein
- fatty acid
- randomized controlled trial
- single cell
- insulin resistance
- transcription factor
- electronic health record
- signaling pathway
- ischemia reperfusion injury
- type diabetes
- liver injury
- machine learning
- bone marrow
- climate change
- skeletal muscle
- amino acid
- metabolic syndrome
- drug induced
- deep learning