PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression.
Yi Fei LeeCheryl Zi Jin PhuaJu YuanBin ZhangMay Yin LeeSrinivasaraghavan KannanYui Hei Jasper ChiuCasslynn Wei Qian KohChoon Kong YapEdwin Kok Hao LimJianbin ChenYuhua LimJane Jia Hui LeeAnders Jacobsen SkanderupZhenxun WangWeiwei ZhaiNguan Soon TanChandra S VermaYvonne TayDaniel Shao-Weng TanWai Leong TamPublished in: Genome medicine (2024)
PARP4 is a novel modulator of lung adenocarcinoma, where its tumor suppressive activity is mediated not through the vault complex-unlike conventionally thought, but in association with its novel interaction partner hnRNPM, thus suggesting a role for splicing dysregulation in LUAD tumorigenesis.