N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.
Arielle CimenoWessam HassaneinBeth M FrenchJessica M PowellLars BurdorfOlga GoloubevaXiangfei ChengDawn M ParsellJagdeece RamsoondarKasinath KuraviTodd VaughtMehmet C UluerEmily ReddingNatalie O'NeillChristopher LairdAlena HershfeldIvan TatarovKathryn ThomasDavid AyaresAgnes M AzimzadehRichard N PiersonRolf N BarthJohn C LaMattinaPublished in: Xenotransplantation (2017)
The lack of Neu5Gc expression attenuated erythrocyte loss but did not prevent profound early onset thrombocytopenia or platelet activation, although TXB2 levels were decreased in the presence of Neu5GcKO.