Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations.
Azadeh C BashiElizabeth A CokerKrishna C BulusuPatricia JaaksClaire CrafterHoward LightfootMarta MiloKatrina McCartenDavid F JenkinsDieudonne van der MeerJames T LynchSyd BarthorpeCourtney L AndersenSimon T BarryAlexandra BeckJustin CidadoJacob A GordonCaitlin HallJames A HallIman MaliTatiana MironenkoKevin MongeonJames MorrisLaura RichardsonPaul D SmithOmid TavanaCharlotte TolleyFrances ThomasBrandon S WillisWanjuan YangLenka Oplustil O'ConnorUltan McDermottSusan E CritchlowLisa DrewStephen E FawellJerome T MettetalMathew J GarnettPublished in: Cancer discovery (2024)
We present the largest cancer drug combination screen published to date with 7 × 7 concentration response matrices for 109 combinations in more than 750 cell lines, complemented by multi-omics predictors of response and identification of "emergent" combination biomarkers. We prioritize hits to optimize clinical translatability, and experimentally validate novel combination hypotheses. This article is featured in Selected Articles from This Issue, p. 695.