Lenka Oplustil O'Connor (Mark J O'Connor, Mark O'Connor)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 20

Top Topics

Breast Cancer Cells

Radical Prostatectomy

Dna Damage Response

Top Venues

Cancer discovery

Clinical cancer research : an official journal of the American Association for Cancer Research

Cancer research

Molecular cancer therapeutics

This page only lists publications with an associated author ORCID identifier.

Publications

Azadeh C Bashi, Elizabeth A Coker, Krishna C Bulusu, Patricia Jaaks, Claire Crafter, Howard Lightfoot, Marta Milo, Katrina McCarten, David F Jenkins, Dieudonne van der Meer, James T Lynch, Syd Barthorpe, Courtney L Andersen, Simon T Barry, Alexandra Beck, Justin Cidado, Jacob A Gordon, Caitlin Hall, James A Hall, Iman Mali, Tatiana Mironenko, Kevin Mongeon, James Morris, Laura Richardson, Paul D Smith, Omid Tavana, Charlotte Tolley, Frances Thomas, Brandon S Willis, Wanjuan Yang, Lenka Oplustil O'Connor, Ultan McDermott, Susan E Critchlow, Lisa Drew, Stephen E Fawell, Jerome T Mettetal, Mathew J Garnett
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations. Cancer discovery 14 (5) (2024)
Azadeh C Bashi, Elizabeth A Coker, Krishna C Bulusu, Patricia Jaaks, Claire Crafter, Howard Lightfoot, Marta Milo, Katrina McCarten, David F Jenkins, Dieudonne van der Meer, James T Lynch, Syd Barthorpe, Courtney L Andersen, Simon T Barry, Alexandra Beck, Justin Cidado, Jacob A Gordon, Caitlin Hall, James A Hall, Iman Mali, Tatiana Mironenko, Kevin Mongeon, James Morris, Laura Richardson, Paul D Smith, Omid Tavana, Charlotte Tolley, Frances Thomas, Brandon S Willis, Wanjuan Yang, Lenka Oplustil O'Connor, Ultan McDermott, Susan E Critchlow, Lisa Drew, Stephen E Fawell, Jerome T Mettetal, Mathew J Garnett
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations. Cancer discovery (2024)
Azadeh C Bashi, Elizabeth A Coker, Krishna C Bulusu, Patricia Jaaks, Claire Crafter, Howard Lightfoot, Marta Milo, Katrina McCarten, David F Jenkins, Dieudonne van der Meer, James T Lynch, Syd Barthorpe, Courtney L Andersen, Simon T Barry, Alexandra Beck, Justin Cidado, Jacob A Gordon, Caitlin Hall, James A Hall, Iman Mali, Tatiana Mironenko, Kevin Mongeon, James Morris, Laura Richardson, Paul D Smith, Omid Tavana, Charlotte Tolley, Frances Thomas, Brandon S Willis, Wanjuan Yang, Lenka Oplustil O'Connor, Ultan McDermott, Susan E Critchlow, Lisa Drew, Stephen E Fawell, Jerome T Mettetal, Mathew J Garnett
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations. Cancer discovery 14 (5) (2024)
Azadeh C Bashi, Elizabeth A Coker, Krishna C Bulusu, Patricia Jaaks, Claire Crafter, Howard Lightfoot, Marta Milo, Katrina McCarten, David F Jenkins, Dieudonne van der Meer, James T Lynch, Syd Barthorpe, Courtney L Andersen, Simon T Barry, Alexandra Beck, Justin Cidado, Jacob A Gordon, Caitlin Hall, James A Hall, Iman Mali, Tatiana Mironenko, Kevin Mongeon, James Morris, Laura Richardson, Paul D Smith, Omid Tavana, Charlotte Tolley, Frances Thomas, Brandon S Willis, Wanjuan Yang, Lenka Oplustil O'Connor, Ultan McDermott, Susan E Critchlow, Lisa Drew, Stephen E Fawell, Jerome T Mettetal, Mathew J Garnett
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations. Cancer discovery 14 (5) (2024)
Azadeh C Bashi, Elizabeth A Coker, Krishna C Bulusu, Patricia Jaaks, Claire Crafter, Howard Lightfoot, Marta Milo, Katrina McCarten, David F Jenkins, Dieudonne van der Meer, James T Lynch, Syd Barthorpe, Courtney L Andersen, Simon T Barry, Alexandra Beck, Justin Cidado, Jacob A Gordon, Caitlin Hall, James A Hall, Iman Mali, Tatiana Mironenko, Kevin Mongeon, James Morris, Laura Richardson, Paul D Smith, Omid Tavana, Charlotte Tolley, Frances Thomas, Brandon S Willis, Wanjuan Yang, Lenka Oplustil O'Connor, Ultan McDermott, Susan E Critchlow, Lisa Drew, Stephen E Fawell, Jerome T Mettetal, Mathew J Garnett
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations. Cancer discovery 14 (5) (2024)
Azadeh C Bashi, Elizabeth A Coker, Krishna C Bulusu, Patricia Jaaks, Claire Crafter, Howard Lightfoot, Marta Milo, Katrina McCarten, David F Jenkins, Dieudonne van der Meer, James T Lynch, Syd Barthorpe, Courtney L Andersen, Simon T Barry, Alexandra Beck, Justin Cidado, Jacob A Gordon, Caitlin Hall, James A Hall, Iman Mali, Tatiana Mironenko, Kevin Mongeon, James Morris, Laura Richardson, Paul D Smith, Omid Tavana, Charlotte Tolley, Frances Thomas, Brandon S Willis, Wanjuan Yang, Lenka Oplustil O'Connor, Ultan McDermott, Susan E Critchlow, Lisa Drew, Stephen E Fawell, Jerome T Mettetal, Mathew J Garnett
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations. Cancer discovery (2024)
Anna D Staniszewska, Domenic Pilger, Sonja J Gill, Kunzah Jamal, Natacha Bohin, Sofia Guzzetti, Jacob A Gordon, Gregory Hamm, Gill Mundin, Giuditta Illuzzi, Andy Pike, Lisa McWilliams, Gareth A Maglennon, Jonathan Rose, Glen Hawthorne, Miguel A Cortés González, Christer Halldin, Peter Johnström, Magnus Schou, Susan E Critchlow, Stephen E Fawell, Jeffrey W Johannes, Elisabetta Leo, Barry R Davies, Sabina Cosulich, Jann N Sarkaria, Lenka Oplustil O'Connor, Petra Hamerlik
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Fiona Simpkins, Yasuto Kinose, Haineng Xu, Hyoung Kim, Sushil Kumar, Xiaoyin Shan, Erin Geroge, Xiaolei Wang, Sergey Medvedev, Benjamin Ferman, Sarah Gitto, Margaret Whicker, Kurt D Andrea, Bradley Wubbenhorst, Dorothy Hallberg, Lenka Oplustil O'Connor, Lauren Schwartz, Wei-Ting Hwang, Katherine L Nathanson, Gordon B Mills, Victor E Velculescu, Tian-Li Wang, Eric Brown, Ronny Drapkin
Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancer. Research square (2023)
Zhi Ling Teo, Lenka Oplustil O'Connor, Stephanie Versaci, Kylie A Clarke, Emmaline R Brown, Luke W Percy, Keilly Kuykhoven, Christopher P Mintoff, Peter Savas, Balaji Virassamy, Stephen J Luen, Ann Byrne, Sneha Sant, Geoffrey J Lindeman, Phillip K Darcy, Sherene Loi
Combined PARP and WEE1 inhibition triggers anti-tumor immune response in BRCA1/2 wildtype triple-negative breast cancer. NPJ breast cancer 9 (1) (2023)
Benedetta Pellegrino, Andrea Herencia-Ropero, Alba Llop-Guevara, Flaminia Pedretti, Alejandro Moles-Fernández, Cristina Viaplana, Guillermo Villacampa, Marta Guzmán, Olga Rodríguez, Judit Grueso, Jose Jiménez, Enrique J Arenas, Andrea Degasperi, Joao M L Dias, Josep V Forment, Lenka Oplustil O'Connor, Olivier Déas, Stefano Cairo, Yinghui Zhou, Antonino Musolino, Carlos Caldas, Serena Nik-Zainal, Robert B Clarke, Paolo G Nuciforo, Orland Díez, Xavier Serres-Créixams, Vicente Peg, Martín Espinosa-Bravo, Teresa Macarulla, Ana Oaknin, Joaquin Mateo, Joaquín Arribas, Rodrigo Dienstmann, Meritxell Bellet-Ezquerra, Mafalda Oliveira, Cristina Saura, Sara Gutiérrez-Enríquez, Judith Balmaña, Violeta Serra
Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification. Cancer research 82 (8) (2022)
Violeta Serra, Anderson T Wang, Marta Castroviejo-Bermejo, Urszula M Polanska, Marta Palafox, Andrea Herencia-Ropero, Gemma N Jones, Zhongwu Lai, Joshua Armenia, Filippos Michopoulos, Alba Llop-Guevara, Rachel Brough, Aditi Gulati, Stephen J Pettitt, Krishna C Bulusu, Jenni Nikkilä, Zena Wilson, Adina M Hughes, Paul W G Wijnhoven, Ambar Ahmed, Alejandra Bruna, Albert Gris-Oliver, Marta Guzman, Olga Rodríguez, Judit Grueso, Joaquín Arribas, Javier Cortes, Cristina Saura, Alan Lau, Susan E Critchlow, Brian Dougherty, Carlos Caldas, Gordon B Mills, J Carl Barrett, Josep V Forment, Elaine B Cadogan, Christopher J Lord, Cristina Cruz, Judith Balmaña, Lenka Oplustil O'Connor
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (20) (2022)
Kunzah Jamal, Alessandro Galbiati, Joshua Armenia, Giuditta Illuzzi, James A Hall, Sabrina Bentouati, Daniel Barrell, Miika Ahdesmäki, null null, Lenka Oplustil O'Connor, Elisabetta Leo, Josep V Forment
Drug-gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition. Cancer research communications 2 (10) (2022)
Giuditta Illuzzi, Anna D Staniszewska, Sonja J Gill, Andy Pike, Lisa McWilliams, Susan E Critchlow, Anna Cronin, Stephen E Fawell, Glen Hawthorne, Kunzah Jamal, Jeffrey W Johannes, Emilyanne Leonard, Ruth Macdonald, Gareth A Maglennon, Jenni Nikkilä, Lenka Oplustil O'Connor, Aaron Smith, Harriet Southgate, Joanne Wilson, James W T Yates, Sabina Cosulich, Elisabetta Leo
Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (21) (2022)
Zena Wilson, Rajesh Odedra, Yann Wallez, Paul W G Wijnhoven, Adina M Hughes, Joe Gerrard, Gemma N Jones, Hannah Bargh-Dawson, Elaine Brown, Lucy A Young, Lenka Oplustil O'Connor, Alan Lau
ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib. Cancer research 82 (6) (2022)
Kunzah Jamal, Alessandro Galbiati, Joshua Armenia, Giuditta Illuzzi, James A Hall, Sabrina Bentouati, Daniel Barrell, Miika Ahdesmäki, null null, Lenka Oplustil O'Connor, Elisabetta Leo, Josep V Forment
Drug-gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition. Cancer research communications 2 (10) (2022)
Sonja J Gill, Paul W G Wijnhoven, Jacqueline H L Fok, Rebecca L Lloyd, Jonathan Cairns, Joshua Armenia, Jenni Nikkilä, Alan Lau, Christopher J Bakkenist, Susan M Galbraith, Conchita Vens, Lenka Oplustil O'Connor
Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development. Molecular cancer therapeutics 20 (9) (2021)
Patrick G Pilié, Carl M Gay, Lauren A Byers, Lenka Oplustil O'Connor, Timothy A Yap
PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research 25 (13) (2019)
Lucy C Riches, Antonio G Trinidad, Adina M Hughes, Gemma N Jones, Andrew G Thomason, Paul Gavine, Andy Cui, Stephanie Ling, Jonathan Stott, Roger Clark, Samantha Peel, Pendeep Gill, Louise M Goodwin, Aaron Smith, Kurt G Pike, Bernard Barlaam, Martin Pass, Lenka Oplustil O'Connor, Graeme Smith, Elaine B Cadogan
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically. Molecular cancer therapeutics 19 (1) (2019)
Lucy A Young, Lenka Oplustil O'Connor, Christelle de Renty, Margaret H Veldman-Jones, Thierry Dorval, Zena Wilson, David R Jones, Deborah Lawson, Rajesh Odedra, Apolinar Maya-Mendoza, Corinne Reimer, Jiri Bartek, Alan Lau
Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress. Cancer research 79 (14) (2019)
Ahrum Min, Hyemin Jang, Seongyeong Kim, Kyung-Hun Lee, Debora Keunyoung Kim, Koung Jin Suh, Yaewon Yang, Paul Elvin, Lenka Oplustil O'Connor, Seock-Ah Im
Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response. Molecular cancer therapeutics 17 (12) (2018)