Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial.

Christian Otte Woo Ri ChaeJan NowackiMichael KaczmarczykDominique PiberStefan RoepkeStefanie MärschenzSandra LischewskiSein SchmidtBarbara EttrichHans Joergen GrabeUlrich HegerlKim HinkelmannTobias HofmannDeborah JanowitzKlaus JunghannsKai G KahlJan-Philipp KleinTillmann H C KruegerGregor LeichtDavid PrvulovicAndreas ReifDaniel SchoettleMaria StraussAnna WestermairTim Friede Stefan M Gold

Published in: BMJ open (2020)

NCT04301271, DRKS00021119, EudraCT 2018-002947-27.

Keyphrases

double blind
study protocol
placebo controlled
clinical trial
insulin resistance
metabolic syndrome
weight loss
major depressive disorder
type diabetes
high fat diet induced
weight gain
open label
phase iii
randomized controlled trial
phase ii
adipose tissue