Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated with Haemophilus influenzae Meningitis in a Newborn.
Noely Evangelista FerreiraAntonio Charlys da CostaEsper G KallasCassia G T SilveiraAna Carolina S de OliveiraLayla HonoratoHeuder G O PaiãoSilvia H LimaDewton de M VasconcelosMarina F CôrtesSilvia F CostaTania R T MendozaHélio R GomesSteven S WitkinMaria Cássia Mendes-CorreaPublished in: Current issues in molecular biology (2023)
Parvovirus B19 infection is associated with a wide range of clinical manifestations, from asymptomatic to severe neurological disorders. Its major clinical symptoms, fever and rash, are common to multiple viruses, and laboratory tests to detect B19 are frequently not available. Thus, the impact of B19 on public health remains unclear. We report the case of a 38-day old girl admitted to São Paulo Clinical Hospital, Brazil, with an initial diagnosis of bacterial meningitis, seizures, and acute hydrocephalus. Antibiotic therapy was maintained for one week after admission and discontinued after negative laboratory results were obtained. Nine days after symptoms onset, a cerebral spinal fluid (CSF) sample revealed persistent pleocytosis. The complete B19 complete genome was subsequently identified in her CSF by a metagenomic next-generation sequencing approach. This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations and emphasizes that its possible involvement might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.
Keyphrases
- public health
- cerebrospinal fluid
- liver failure
- endothelial cells
- emergency department
- healthcare
- drug induced
- subarachnoid hemorrhage
- respiratory failure
- randomized controlled trial
- spinal cord
- cerebral ischemia
- aortic dissection
- spinal cord injury
- dna methylation
- sleep quality
- antibiotic resistance genes
- copy number
- mesenchymal stem cells
- wastewater treatment
- blood brain barrier
- genetic diversity
- pluripotent stem cells
- induced pluripotent stem cells
- chemotherapy induced