The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer.
Rui GuoYu ChenHeather BorgardMayumi JijiwaMasaki NasuMin HeYouping DengPublished in: Molecules (Basel, Switzerland) (2020)
Lipids are essential components of cell structure and play important roles in signal transduction between cells and body metabolism. With the continuous development and innovation of lipidomics technology, many studies have shown that the relationship between lipids and cancer is steadily increasing, involving cancer occurrence, proliferation, migration, and apoptosis. Breast cancer has seriously affected the safety and quality of life of human beings worldwide and has become a significant public health problem in modern society, with an especially high incidence among women. Therefore, the issue has inspired scientific researchers to study the link between lipids and breast cancer. This article reviews the research progress of lipidomics, the biological characteristics of lipid molecules, and the relationship between some lipids and cancer drug resistance. Furthermore, this work summarizes the lipid molecules related to breast cancer diagnosis and prognosis, and then it clarifies their impact on the occurrence and development of breast cancer The discussion revolves around the current research hotspot long-chain non-coding RNAs (lncRNAs), summarizes and explains their impact on tumor lipid metabolism, and provides more scientific basis for future cancer research studies.
Keyphrases
- papillary thyroid
- public health
- fatty acid
- squamous cell
- childhood cancer
- risk assessment
- randomized controlled trial
- oxidative stress
- endothelial cells
- lymph node metastasis
- systematic review
- induced apoptosis
- cell death
- single cell
- stem cells
- polycystic ovary syndrome
- cell proliferation
- skeletal muscle
- adipose tissue
- endoplasmic reticulum stress
- type diabetes
- drug induced