The Effect of Increased Intra-Abdominal Pressure on Hemodynamics in Laparoscopic Cholecystectomy-The Experience of a Single Centre.

Laparoscopic cholecystectomy is characterized by reduced postoperative pain, shorter hospital stays, rapid return to preoperative physical activity, and less psychological impact on the patient. During laparoscopic cholecystectomy, the intra-abdominal insufflation of carbon dioxide with secondary increase in intra-abdominal pressure can cause important hemodynamic consequences, like decreased cardiac output and blood pressure, as well as compensatory increase in heart rate. The purpose of this study is to evaluate changes in cardiovascular parameters during general anesthesia in patients undergoing laparoscopic cholecystectomy. Retrospective data from 342 patients with cholecystectomy for cholelithiasis performed at Railway Hospital Galati, Romania, were reviewed. All patients received the same intraoperative anesthetics. Female patients were 85.7% ( n = 293). More than half of the patients, 53.51% ( n = 183), were 40-59 years old, and only 16.37% ( n = 56) were under 40 years old. Patients with a normal body mass index (BMI) represented 45.6% ( n = 156), 33.3% ( n = 114) were underweight, and 12% ( n = 42) had grade 1 obesity (BMI 25-29.9 kg/m 2 ). The minimum intraoperative blood pressure correlated with patient gender ( p 0.015 < 0.005), with men having a higher blood pressure than women ( p 0.006 < 0.05), and for BMI, a higher BMI was associated with elevated blood pressure ( p 0.025 < 0.05). Older age correlated with an increased maximum intraoperative blood pressure ( p < 0.001 < 0.05) and with maximum intraoperative heart rate ( p 0.015 < 0.05). Patients undergoing laparoscopic cholecystectomy experienced significant hemodynamic changes with pneumoperitoneum, but this type of surgical intervention was safe for patients regardless of their age.