Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension.

Qingqing Chu Yujia Li Jichao Wu Yanjiao Gao Xiangyun Guo Jing Li Hang LvMin LiuWei Tang Peng Zhan Tao ZhangHuili HuHong LiuJinpeng SunXiaojie WangFan Yi

Published in: Circulation research (2024)

This study discovers a previously unrecognized role of GPR183 in promoting endothelial senescence. Pharmacological targeting of GPR183 may be an innovative therapeutic strategy for hypertension and its associated complications.

Keyphrases

endothelial cells
blood pressure
fatty acid
dna damage
stress induced
risk factors
oxidative stress