Peng Zhan

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 56

Top Topics

Molecular Docking

Men Who Have Sex With Men

Human Immunodeficiency Virus

Top Venues

Journal of medicinal chemistry

Chemical biology & drug design

Communications chemistry

RSC medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Zihao Sang, Tao Zhang, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Design and synthesis of Fsp 3 -enriched spirocyclic-substituted diarylpyrimidine derivatives as novel HIV-1 NNRTIs. Chemical biology & drug design 103 (3) (2024)
Zhenzhen Zhou, Weifeng Zhang, Fabao Zhao, Yanying Sun, Na Wang, Jie Cheng, Peng Zhan, Fan Yang, Jin-Peng Sun, Xinyong Liu, Dongwei Kang
Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates. Journal of medicinal chemistry 67 (5) (2024)
Zhenzhen Zhou, Weifeng Zhang, Fabao Zhao, Yanying Sun, Na Wang, Jie Cheng, Peng Zhan, Fan Yang, Jin-Peng Sun, Xinyong Liu, Dongwei Kang
Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates. Journal of medicinal chemistry (2024)
Zihao Sang, Tao Zhang, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Design and synthesis of Fsp 3 -enriched spirocyclic-substituted diarylpyrimidine derivatives as novel HIV-1 NNRTIs. Chemical biology & drug design 103 (3) (2024)
Zhenzhen Zhou, Weifeng Zhang, Fabao Zhao, Yanying Sun, Na Wang, Jie Cheng, Peng Zhan, Fan Yang, Jin-Peng Sun, Xinyong Liu, Dongwei Kang
Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates. Journal of medicinal chemistry 67 (5) (2024)
Shaoqing Du, Xinyong Liu, Xueping Hu, Peng Zhan
Viral Protein Dimerization Quality Control: A Design Strategy for a Potential Viral Inhibitor. Journal of medicinal chemistry (2024)
Xiaoyu Shi, Tong Zhao, Shuo Wang, Shujing Xu, Hui Liao, Shenghua Gao, Zhen Gao, Jian Zhang, Danhui Qi, Zhijiao Zhang, Fengxin Zheng, Youzhao Wang, Zhenqian Wang, Mingyu Yang, Qian Yang, Fan Yi, Jianxin Pang, Xinyong Liu, Peng Zhan
Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability. Journal of medicinal chemistry 67 (6) (2024)
Zongji Zhuo, Zhao Wang, Lanlan Jing, Tao Zhang, Anchao Ge, Zhenzhen Zhou, Ying Liu, Xin Li, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang
Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2- d ]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation. International journal of molecular sciences 25 (16) (2024)
Zongji Zhuo, Zhao Wang, Lanlan Jing, Tao Zhang, Anchao Ge, Zhenzhen Zhou, Ying Liu, Xin Li, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang
Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2- d ]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation. International journal of molecular sciences 25 (16) (2024)
Qingqing Chu, Yujia Li, Jichao Wu, Yanjiao Gao, Xiangyun Guo, Jing Li, Hang Lv, Min Liu, Wei Tang, Peng Zhan, Tao Zhang, Huili Hu, Hong Liu, Jinpeng Sun, Xiaojie Wang, Fan Yi
Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension. Circulation research (2024)
Xiaoyu Shi, Tong Zhao, Shuo Wang, Shujing Xu, Hui Liao, Shenghua Gao, Zhen Gao, Jian Zhang, Danhui Qi, Zhijiao Zhang, Fengxin Zheng, Youzhao Wang, Zhenqian Wang, Mingyu Yang, Qian Yang, Fan Yi, Jianxin Pang, Xinyong Liu, Peng Zhan
Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability. Journal of medicinal chemistry 67 (6) (2024)
Yanying Sun, Zhenzhen Zhou, Na Wang, Fabao Zhao, Ying Liu, Xiaoxuan Xu, Xiaohan Wang, Zhenbang Gou, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs. Journal of medicinal chemistry (2024)
Xiaoyu Shi, Tong Zhao, Shuo Wang, Shujing Xu, Hui Liao, Shenghua Gao, Zhen Gao, Jian Zhang, Danhui Qi, Zhijiao Zhang, Fengxin Zheng, Youzhao Wang, Zhenqian Wang, Mingyu Yang, Qian Yang, Fan Yi, Jianxin Pang, Xinyong Liu, Peng Zhan
Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability. Journal of medicinal chemistry (2024)
Yanying Sun, Zhenzhen Zhou, Na Wang, Fabao Zhao, Ying Liu, Xiaoxuan Xu, Xiaohan Wang, Zhenbang Gou, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs. Journal of medicinal chemistry 67 (8) (2024)
Fabao Zhao, Heng Zhang, Minghui Xie, Bairu Meng, Na Liu, Caiyun Dun, Yanyang Qin, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Ya-Jie Tang, Peng Zhan, Xinyong Liu, Dongwei Kang
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. Journal of medicinal chemistry 66 (3) (2023)
Zhao Wang, Prem Prakash Sharma, Brijesh Rathi, Minghui Xie, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3- d ]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles. Journal of medicinal chemistry (2023)
Huinan Jia, Lide Hu, Jiwei Zhang, Xing Huang, Yuanmin Jiang, Guanyu Dong, Chuanfeng Liu, Xinyong Liu, Meehyein Kim, Peng Zhan
Recent advances of phenotypic screening strategies in the application of anti-influenza virus drug discovery. RSC medicinal chemistry 15 (1) (2023)
Shujing Xu, Lin Sun, Michael Barnett, Xujie Zhang, Dang Ding, Anushka Gattu, Dazhou Shi, Jamie R H Taka, Wenli Shen, Xiangyi Jiang, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, David C Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan
Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators. Journal of medicinal chemistry (2023)
Shenghua Gao, Letian Song, Katharina Sylvester, Beatrice Mercorelli, Arianna Loregian, Karoly Toth, Renato H Weiße, Abibe Useini, Norbert Sträter, Mianling Yang, Bing Ye, Ann E Tollefson, Christa Elisabeth Müller, Xinyong Liu, Peng Zhan
Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability. Journal of medicinal chemistry (2023)
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors. Communications chemistry 6 (1) (2023)
Fabao Zhao, Heng Zhang, Minghui Xie, Bairu Meng, Na Liu, Caiyun Dun, Yanyang Qin, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Ya-Jie Tang, Peng Zhan, Xinyong Liu, Dongwei Kang
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. Journal of medicinal chemistry 66 (3) (2023)
Fabao Zhao, Heng Zhang, Minghui Xie, Bairu Meng, Na Liu, Caiyun Dun, Yanyang Qin, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Ya-Jie Tang, Peng Zhan, Xinyong Liu, Dongwei Kang
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. Journal of medicinal chemistry 66 (3) (2023)
Ping Li, Han Ju, Yihong Xing, Fabao Zhao, Varada Anirudhan, Ruikun Du, Qinghua Cui, Xinyong Liu, Lijun Rong, Peng Zhan
Identification of the Imidazo[1,2- a ]pyrazine Derivative A4 as a Potential Influenza Virus Nucleoprotein Inhibitor. ACS pharmacology & translational science 6 (12) (2023)
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors. Communications chemistry 6 (1) (2023)
Fabao Zhao, Heng Zhang, Minghui Xie, Bairu Meng, Na Liu, Caiyun Dun, Yanyang Qin, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Ya-Jie Tang, Peng Zhan, Xinyong Liu, Dongwei Kang
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. Journal of medicinal chemistry (2023)
Huinan Jia, Lide Hu, Jiwei Zhang, Xing Huang, Yuanmin Jiang, Guanyu Dong, Chuanfeng Liu, Xinyong Liu, Meehyein Kim, Peng Zhan
Recent advances of phenotypic screening strategies in the application of anti-influenza virus drug discovery. RSC medicinal chemistry 15 (1) (2023)
Han Ju, Lingxin Hou, Fabao Zhao, Ying Zhang, Ruifang Jia, Laura Guizzo, Anna Bonomini, Jiwei Zhang, Zhen Gao, Ruipeng Liang, Chiara Bertagnin, Xiujie Kong, Xiuli Ma, Dongwei Kang, Arianna Loregian, Bing Huang, Xinyong Liu, Peng Zhan
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity. Journal of medicinal chemistry 65 (17) (2022)
Shenghua Gao, Letian Song, Tobias Claff, Molly Woodson, Katharina Sylvester, Lanlan Jing, Renato H Weiße, Yusen Cheng, Norbert Sträter, Laura Schäkel, Michael Gütschow, Bing Ye, Mianling Yang, Tao Zhang, Dongwei Kang, Karoly Toth, John E Tavis, Ann E Tollefson, Christa Elisabeth Müller, Peng Zhan, Xinyong Liu
Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors. Journal of medicinal chemistry (2022)
Yanying Sun, Zhenzhen Zhou, Da Feng, Lanlan Jing, Fabao Zhao, Zhao Wang, Tao Zhang, Hao Lin, Hao Song, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang
Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs. Journal of medicinal chemistry 65 (23) (2022)
Zhao Wang, Srinivasulu Cherukupalli, Minghui Xie, Wenbo Wang, Xiangyi Jiang, Ruifang Jia, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Peng Zhan, Xinyong Liu
Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors. Journal of medicinal chemistry 65 (5) (2022)
Tong Zhao, Jian Zhang, Yucen Tao, Hui Liao, Fabao Zhao, Ruipeng Liang, Xiaoyu Shi, Zhijiao Zhang, Jianbo Ji, Ting Wu, Jianxin Pang, Xinyong Liu, Peng Zhan
Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability. Journal of medicinal chemistry 65 (5) (2022)
Dongwei Kang, Yanying Sun, Da Feng, Shenghua Gao, Zhao Wang, Lanlan Jing, Tao Zhang, Xiangyi Jiang, Hao Lin, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Development of Novel Dihydrofuro[3,4- d ]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C. Journal of medicinal chemistry 65 (3) (2022)
Shenghua Gao, Katharina Sylvester, Letian Song, Tobias Claff, Lanlan Jing, Molly Woodson, Renato H Weiße, Yusen Cheng, Laura Schäkel, Marvin Petry, Michael Gütschow, Anke C Schiedel, Norbert Sträter, Dongwei Kang, Shujing Xu, Karoly Toth, John E Tavis, Ann E Tollefson, Christa Elisabeth Müller, Xinyong Liu, Peng Zhan
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity. Journal of medicinal chemistry 65 (19) (2022)
Han Ju, Murugan Natarajan Arul, Lingxin Hou, Ping Li, Laura Guizzo, Ying Zhang, Chiara Bertagnin, Xiujie Kong, Dongwei Kang, Ruifang Jia, Xiuli Ma, Ruikun Du, Vasanthanathan Poongavanam, Arianna Loregian, Bing Huang, Xinyong Liu, Peng Zhan
Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability. Journal of medicinal chemistry (2021)
Zhao Wang, Waleed A Zalloum, Wenbo Wang, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles. Journal of medicinal chemistry 64 (18) (2021)
Dongwei Kang, Francesc X Ruiz, Yanying Sun, Da Feng, Lanlan Jing, Zhao Wang, Tao Zhang, Shenghua Gao, Lin Sun, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Peng Zhan, Xinyong Liu
2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. Journal of medicinal chemistry 64 (7) (2021)
Boshi Huang, Tiziana Ginex, Francisco Javier Luque, Xiangyi Jiang, Ping Gao, Jian Zhang, Dongwei Kang, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies. Journal of medicinal chemistry 64 (18) (2021)
Siyu Xiu, Alexej Dick, Han Ju, Sako Mirzaie, Fatemeh Abdi, Simon Cocklin, Peng Zhan, Xinyong Liu
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities. Journal of medicinal chemistry 63 (21) (2020)
Dongwei Kang, Da Feng, Yanying Sun, Zengjun Fang, Fenju Wei, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties. Journal of medicinal chemistry 63 (9) (2020)
Boshi Huang, Dongwei Kang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Design, synthesis, and biological evaluation of piperidinyl-substituted [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential anti-HIV-1 agents with reduced cytotoxicity. Chemical biology & drug design 97 (1) (2020)
Dongwei Kang, Yanying Sun, Murugan Natarajan Arul, Da Feng, Fenju Wei, Jing Li, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs. ACS infectious diseases 6 (8) (2020)
Dongwei Kang, F Xavier Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Xinyong Liu, Peng Zhan
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. Journal of medicinal chemistry 63 (3) (2020)
Tong Zhao, Qing Meng, Zhuosen Sun, Yanyu Chen, Wei Ai, Zean Zhao, Dongwei Kang, Yue Dong, Ruipeng Liang, Ting Wu, Jianxin Pang, Xinyong Liu, Peng Zhan
Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability. Journal of medicinal chemistry 63 (19) (2020)
Ping Gao, Xueshun Wang, Lin Sun, Xiqiang Cheng, Vasanthanathan Poongavanam, Jacob Kongsted, Mar Álvarez, Joanna Luczkowiak, Christophe Pannecouque, Erik De Clercq, Kuo-Hsiung Lee, Chin-Ho Chen, Huiqing Liu, Luis Menéndez-Arias, Xinyong Liu, Peng Zhan
Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors. Chemical biology & drug design 93 (4) (2019)
Boshi Huang, Wenmin Chen, Tong Zhao, Zhenyu Li, Xiangyi Jiang, Tiziana Ginex, David Vílchez, Francisco Javier Luque, Dongwei Kang, Ping Gao, Jian Zhang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles. Journal of medicinal chemistry 62 (4) (2019)
Gaochan Wu, Tong Zhao, Dongwei Kang, Jian Zhang, Yuning Song, Vigneshwaran Namasivayam, Jacob Kongsted, Christophe Pannecouque, Erik De Clercq, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan
Overview of Recent Strategic Advances in Medicinal Chemistry. Journal of medicinal chemistry 62 (21) (2019)
Dongwei Kang, Heng Zhang, Zhao Wang, Tong Zhao, Tiziana Ginex, Francisco Javier Luque, Yang Yang, Gaochan Wu, Da Feng, Fenju Wei, Jian Zhang, Erik De Clercq, Christophe Pannecouque, Chin Ho Chen, Kuo-Hsiung Lee, N Arul Murugan, Thomas A Steitz, Peng Zhan, Xinyong Liu
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. Journal of medicinal chemistry 62 (3) (2019)
Dongwei Kang, Zhao Wang, Meng Chen, Da Feng, Gaochan Wu, Zhongxia Zhou, Lanlan Jing, Xiaofang Zuo, Xiangyi Jiang, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I. Chemical biology & drug design 93 (4) (2019)
Xiangyi Jiang, Ji Yu, Zhongxia Zhou, Jacob Kongsted, Yuning Song, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan
Molecular design opportunities presented by solvent-exposed regions of target proteins. Medicinal research reviews 39 (6) (2019)
Peng Zhan, Dongwei Kang, Xinyong Liu
Resurrecting the Condemned: Identification of N-Benzoxaborole Benzofuran GSK8175 as a Clinical Candidate with Reduced Metabolic Liability. Journal of medicinal chemistry 62 (7) (2019)
Vigneshwaran Namasivayam, Murugesan Vanangamudi, Victor G Kramer, Sonali Kurup, Peng Zhan, Xinyong Liu, Jacob Kongsted, Siddappa N Byrareddy
The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic. Journal of medicinal chemistry 62 (10) (2018)
Jian Zhang, Natarajan Arul Murugan, Ye Tian, Chiara Bertagnin, Zengjun Fang, Dongwei Kang, Xiujie Kong, Haiyong Jia, Zhuosen Sun, Ruifang Jia, Ping Gao, Vasanthanathan Poongavanam, Arianna Loregian, Wenfang Xu, Xiuli Ma, Xiao Ding, Bing Huang, Peng Zhan, Xinyong Liu
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant. Journal of medicinal chemistry 61 (22) (2018)
Zhao Wang, Dongwei Kang, Meng Chen, Gaochan Wu, Da Feng, Tong Zhao, Zhongxia Zhou, Zhipeng Huo, Lanlan Jing, Xiaofang Zuo, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors. Chemical biology & drug design 92 (6) (2018)
Han Ju, Jian Zhang, Boshi Huang, Dongwei Kang, Bing Huang, Xinyong Liu, Peng Zhan
Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives. Journal of medicinal chemistry 60 (9) (2017)
Dongwei Kang, Zengjun Fang, Boshi Huang, Xueyi Lu, Heng Zhang, Haoran Xu, Zhipeng Huo, Zhongxia Zhou, Zhao Yu, Qing Meng, Gaochan Wu, Xiao Ding, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants. Journal of medicinal chemistry 60 (10) (2017)
Gaochan Wu, Yun Gao, Dongwei Kang, Boshi Huang, Zhipeng Huo, Huiqing Liu, Vasanthanathan Poongavanam, Peng Zhan, Xinyong Liu
Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors. MedChemComm 9 (1) (2017)