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From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science."

Marko Z NikolićEva M Garrido-MartinFlavia R GreiffoAurélie FabreIrene H HeijinkAgnes BootsCatherine M GreenePieter S HiemstraSabine Bartel
Published in: ERJ open research (2019)
The European Respiratory Society (ERS) International Congress is the largest respiratory congress and brings together leading experts in all fields of respiratory medicine and research. ERS Assembly 3 shapes the basic and translational science aspects of this congress, aiming to combine cutting-edge novel developments in basic research with novel clinical findings. In this article, we summarise a selection of the scientific highlights from the perspective of the three groups within Assembly 3. In particular, we discuss new insights into the pathophysiology of the human alveolus, novel tools in organoid development and (epi)genome editing, as well as insights from the presented abstracts on novel therapeutic targets being identified for idiopathic pulmonary fibrosis.
Keyphrases
  • crispr cas
  • genome editing
  • idiopathic pulmonary fibrosis
  • public health
  • endothelial cells
  • respiratory tract
  • dna methylation
  • gene expression
  • interstitial lung disease
  • pluripotent stem cells