Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study.
Laura AntoliniDiFrancesco Jacopo CosimoMarialuisa ZeddeGianPaolo BassoAndrea ArighiAtsushi ShimaAnnachiara CagninMassimo CauloRoxana O CarareCharidimou AndreasMario CirilloVincenzo Di LazzaroCarlo FerrareseAlessia GiossiDomenico InzitariMichela MarconRoberto MarconiMasafumi IharaRicardo NitriniBerardino OrlandiAlessandro PadovaniRosario PascarellaFrancesco PeriniGiulia PeriniMaria SessaElio ScarpiniTagliavini FabrizioRaffaella ValentiJuan Francisco Vázquez CostaAlberto Villarejo-GalendeYuta HagiwaraNicole ZiliottoFabrizio PiazzaPublished in: Neurology (2021)
These results from the largest longitudinal cohort registry of patients with CAA-ri support the transient and potentially relapsing inflammatory nature of the clinical-radiologic acute manifestations of the disease and the effectiveness of slow oral tapering off after IV corticosteroid pulse therapy in preventing recurrences. Our results highlight the importance of differential diagnosis for spontaneous ARIA-like events in β-amyloid-driven diseases, including treatment-related ARIA in patients with Alzheimer disease exposed to immunotherapy drugs.
Keyphrases
- oxidative stress
- cross sectional
- multiple sclerosis
- drug induced
- randomized controlled trial
- liver failure
- systematic review
- blood pressure
- cerebral ischemia
- subarachnoid hemorrhage
- clinical trial
- stem cells
- rheumatoid arthritis
- mesenchymal stem cells
- intensive care unit
- hepatitis b virus
- replacement therapy
- mechanical ventilation