Mesenchymal Stem Cell Studies in the Goat Model for Biomedical Research-A Review of the Scientific Literature.
Inês E DiasCarlos A ViegasJoão Filipe RequichaMaria José SaavedraJorge T DE AzevedoPedro Pires CarvalhoIsabel R DiasPublished in: Biology (2022)
Mesenchymal stem cells (MSCs) are multipotent cells, defined by their ability to self-renew, while maintaining the capacity to differentiate into different cellular lineages, presumably from their own germinal layer. MSCs therapy is based on its anti-inflammatory, immunomodulatory, and regenerative potential. Firstly, they can differentiate into the target cell type, allowing them to regenerate the damaged area. Secondly, they have a great immunomodulatory capacity through paracrine effects (by secreting several cytokines and growth factors to adjacent cells) and by cell-to-cell contact, leading to vascularization, cellular proliferation in wounded tissues, and reducing inflammation. Currently, MSCs are being widely investigated for numerous tissue engineering and regenerative medicine applications. Appropriate animal models are crucial for the development and evaluation of regenerative medicine-based treatments and eventual treatments for debilitating diseases with the hope of application in upcoming human clinical trials. Here, we summarize the latest research focused on studying the biological and therapeutic potential of MSCs in the goat model, namely in the fields of orthopedics, dermatology, ophthalmology, dentistry, pneumology, cardiology, and urology fields.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- cell therapy
- tissue engineering
- induced apoptosis
- bone marrow
- clinical trial
- cell cycle arrest
- single cell
- anti inflammatory
- signaling pathway
- endothelial cells
- systematic review
- gene expression
- endoplasmic reticulum stress
- randomized controlled trial
- cell death
- cardiac surgery
- artificial intelligence
- high resolution
- acute kidney injury
- pluripotent stem cells
- deep learning
- case control
- study protocol
- cell proliferation
- smoking cessation