Halting coronavirus polymerase.

Published in: The Journal of biological chemistry (2020)

The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.

Keyphrases

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respiratory syndrome coronavirus
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structural basis
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combination therapy
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