PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients.
Yeniley Ruiz-NoaJorge Hernández-BelloMara Anais Llamas-CovarrubiasClaudia Azucena Palafox-SánchezEdith Oregon-RomeroPedro Ernesto Sánchez-HernándezMaria Guadalupe Ramírez-DueñasIsela Parra-RojasJosé Francisco Munoz-VallePublished in: Journal of clinical laboratory analysis (2018)
The PTPN22 1858 T risk allele is associated with increased CD4+ T cells percentage and high mCD154 expression in RA patients, which could favor the pro-inflammatory cytokine release and the establishment of the inflammatory response at the seropositive RA.
Keyphrases
- rheumatoid arthritis patients
- disease activity
- inflammatory response
- poor prognosis
- end stage renal disease
- rheumatoid arthritis
- ejection fraction
- chronic kidney disease
- systemic lupus erythematosus
- peritoneal dialysis
- prognostic factors
- ankylosing spondylitis
- binding protein
- lipopolysaccharide induced
- systemic sclerosis