Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.

Rob G H DriessenDorien KiersCasper SchalkwijkJean ScheijenJelle GerretsenPeter PickkersMarcel van de PollIwan van der HorstDennis BergmansMatthijs KoxBas van Bussel

Published in: Bioscience reports (2022)

Systemic inflammation downregulates glyoxalase-1 mRNA expression in humans. This is a possible mechanism leading to cell damage and multi-organ failure in critical illness with potential for intervention.

Keyphrases

poor prognosis
randomized controlled trial
single cell
cell therapy
oxidative stress
stem cells